Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Idoxifene is a tissue-specific selective estrogen receptor modulator.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 1,100 | 5日内发货 | ||
25 mg | ¥ 8,400 | 6-8周 | ||
50 mg | ¥ 10,800 | 6-8周 | ||
100 mg | ¥ 16,800 | 6-8周 |
产品描述 | Idoxifene is a tissue-specific selective estrogen receptor modulator. |
体外活性 | Idoxifene acts in the bone as an estrogen agonist for osteoblasts and shows negligible agonist activity in human endometrial cells. Idoxifene and E2 protect hepatocytes from inflammatory cell injury by inhibiting activation of the NF-κB proinflammatory transcription factor [2]. Idoxifene possesses the protective roles in vascular smooth muscle cells by blunting the angiotensin II-induced production of reactive oxygen species. Idoxifene evidently suppresses HSC activation, inhibits culture-activated HSC proliferation in a dose-dependent manner, and induces culture-activated HSC apoptosis in a time-dependent manner [1]. |
体内活性 | Idoxifene at doses of over 0.1 mg/kg significantly reduces the hepatic levels of collagen and MDA in the DMN model in a dose-dependent manner. Animals receive daily intraperitoneal injections of Estradiol (0.5 mg/kg) and an oral gavage of Idoxifene (0.02, 0.1, and 0.5 mg/kg) for 3 days after Dimethylnitrosamine (DMN) treatment. Although Idoxifene and E2 are administered by different routes, i.e., by oral ingestion and intraperitoneal injection, respectively. However, the antifibrotic effect of a dose of 0.5 mg/kg of Idoxifene is somewhat greater than that of the same dose of E2 [2]. |
别名 | CB7432 |
分子量 | 523.45 |
分子式 | C28H30INO |
CAS No. | 116057-75-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Idoxifene 116057-75-1 Others CB-7432 CB7432 CB 7432 Inhibitor inhibitor inhibit