Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Heptamidine is an effective Pentamidine-related inhibitor of the calcium-binding protein S100B (Kd: 6.9 μM). It selectively kills melanoma cells with S100B over those without S100B. It is a useful tool for the investigation of Myotonic dystrophy.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
Heptamidine 的其他形式现货产品:
产品描述 | Heptamidine is an effective Pentamidine-related inhibitor of the calcium-binding protein S100B (Kd: 6.9 μM). It selectively kills melanoma cells with S100B over those without S100B. It is a useful tool for the investigation of Myotonic dystrophy. |
靶点活性 | S100B:(kd)6.9 μM |
体外活性 | Heptamidine is a Pentamidine-S100B complex, two molecules of pentamidine bind per monomer of S100B, which is used to be an inhibitor for S100B[1]. Heptamidine rescues mis-splicing of minigene reporters in a HeLa cell DM1 model (EC50 value of 15 μM). When compares to Propamidine and Pentamidine, Heptamidine (20 μM) does not reduce CUG levels?obviously. It shows cytotoxic at concentrations above 17.5 μM in HeLa cells expressing 960 CUG repeats[2]. |
体内活性 | Heptamidine (intraperitoneal injection; 20 or 30 mg/kg; 7 days) induces a dose-dependent reduction of exon 7a inclusion in?HSALR?mice. When at 20 mg/kg dose, returning to wild type levels (6±1%), the myotonia is reduced from grade 3 to grade 1 (occasional myotonic discharge) or grade 0 at both 20 or 30 mg/kg[2]. |
别名 | SBi4211 |
分子量 | 368.47 |
分子式 | C21H28N4O2 |
CAS No. | 94345-47-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Heptamidine 94345-47-8 Others SBi4211 Inhibitor inhibitor inhibit