Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Exicorilant is a selective and oral active glucocorticoid receptor (GR) antagonist (Ki: 7 nM) and it also has the potential to overcome adiposity, glucose intolerance, and dyslipidemia.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 19,400 | 10-14周 | ||
50 mg | ¥ 25,800 | 10-14周 | ||
100 mg | ¥ 33,500 | 10-14周 |
产品描述 | Exicorilant is a selective and oral active glucocorticoid receptor (GR) antagonist (Ki: 7 nM) and it also has the potential to overcome adiposity, glucose intolerance, and dyslipidemia. |
靶点活性 | GR:(ki)7 nM |
体外活性 | Exicorilant reverses corticosterone-mediated GR activity in murine brown adipocytes [1]. |
体内活性 | Exicorilant decreases fat mass, body weight, and plasma lipids in HFD-fed mice. Exicorilant (6, 20, or 60 mg/kg/d, for 3 weeks in mice) at different dosages reduce fat mass, body weight, plasma TG, cholesterol, and FFA in a dose-dependent manner. But it has no effect on lean mass [2]. |
别名 | CORT 125281 |
分子量 | 589.56 |
分子式 | C26H23F4N7O3S |
CAS No. | 1781244-77-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (424.05 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.6962 mL | 8.4809 mL | 16.9618 mL | 42.4045 mL |
5 mM | 0.3392 mL | 1.6962 mL | 3.3924 mL | 8.4809 mL | |
10 mM | 0.1696 mL | 0.8481 mL | 1.6962 mL | 4.2405 mL | |
20 mM | 0.0848 mL | 0.424 mL | 0.8481 mL | 2.1202 mL | |
50 mM | 0.0339 mL | 0.1696 mL | 0.3392 mL | 0.8481 mL | |
100 mM | 0.017 mL | 0.0848 mL | 0.1696 mL | 0.424 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Exicorilant 1781244-77-6 Others CORT125281 CORT-125281 CORT 125281 Inhibitor inhibitor inhibit