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CNDAC

产品编号 T13621L CAS 135598-68-4

CNDAC, a nucleoside analog, is a major metabolite of oral drug sapacitabine. 在相同实验条件下，摩尔浓度相同的化合物盐形式与游离态具有相同的生物活性，但盐形式 CNDAC hydrochloride 的水溶性和稳定性通常比游离态更好。

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CNDAC, CAS 135598-68-4

规格	价格/CNY		货期	数量
25 mg	￥ 10,600		待询

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CNDAC 的其他形式现货产品:

CNDAC hydrochloride

其他形式的 CNDAC:

CNDAC hydrochloride
现货

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述

CNDAC, a nucleoside analog, is a major metabolite of oral drug sapacitabine.

体外活性

CNDAC-induced SSBs can be repaired by the transcription-coupled nucleotide excision repair pathway, whereas lethal DSBs are mainly repaired through homologous recombination and it induces DSBs, which are products of replication, rather than a consequence of induction of apoptosis. Deficiency in two Rad51 paralogs, Rad51D and XRCC3, greatly sensitizes cells to CNDAC. CNDAC shows potent activity against human fibroblasts deficient in ATM or transfected with an empty vector, approximately 30-fold more than cells repleted with full-length ATM cDNA (IC50s: 0.01 μM and 0.3 μM). The Rad51D-null cell line is approximately 50-fold more sensitive to CNDAC (IC50: 0.006 μM) compared to 51D1.3, the Rad51D-repleted line (IC50: 0.32 μM) [1]. CNDAC displays inhibitory activity against HL-60 and THP-1 cells (IC50s: 1.58 μM and 0.84 μM). CNDAC (10?μM) causes a significant drop in cell survival compared to the untreated on days 4, 7, and 14. CNDAC is more effective at reducing the viability and inducing apoptosis than ara-C at equivalent concentrations in the THP-1 cell line [2]. CNDAC causes DNA damage, and DNA-PK and ATR are dispensable for cell survival. CNDAC-induced DNA damage is repaired through the homologous recombination pathway [3].

分子量	252.23
分子式	C10H12N4O4
CAS No.	135598-68-4

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

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参考文献

1. Liu XJ, et al. Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks. hin J Cancer. 2012 Aug;31(8):373-80. 2. Jagan S, et al. Bone Marrow and Peripheral Blood AML Cells Are Highly Sensitive to CNDAC, the Active Form of Sapacitabine. Adv Hematol. 2012;2012:727683. 3. Liu X, et al. Homologous recombination as a resistance mechanism to replication-induced double-strand breaks caused by the antileukemia agent CNDAC. Blood. 2010 Sep 9;116(10):1737-46.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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