Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bafetinib is a potent and selective dual inhibitor of Bcr-Abl/Lyn tyrosine kinase (IC50: 5.8nM and 19nM, respectively).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 708 | 待询 | ||
10 mg | ¥ 1,284 | 待询 | ||
25 mg | ¥ 2,220 | 待询 | ||
100 mg | ¥ 4,425 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,203 | 待询 |
Bafetinib (INNO-406) 的其他形式现货产品:
产品描述 | Bafetinib is a potent and selective dual inhibitor of Bcr-Abl/Lyn tyrosine kinase (IC50: 5.8nM and 19nM, respectively). |
体外活性 | Bafetinib is a specific dual Abl-Lyn inhibitor. For 79 other tyrosine kinases, Bafetinib (0.1μM) can inhibit 4 of these enzymes including Abl, Abl-related gene, Fyn, and Lyn. Bafetinib can block the autophosphorylation of Bcr-Abl. In K562 and 293T cells transfected with wt Bcr-Abl, Bafetinib shows inhibition with IC50 values of 11nM and 22nM, respectively. In the in vitro kinase assays, Bafetinib shows inhibition of a variety of Abl kinase mutants such as M244V, G250E, Y253F, and F317L. It has no effect on T315I in vitro. Bafetinib also suppresses the growth of Bcr-Abl–positive leukemic cell lines including K562, KU812, and BaF3/wt. The BaF3/E255K cells are also sensitive towards Bafetinib. Moreover, Bafetinib is highly potent to inhibit tumor growth in murine tumor models [1]. |
分子量 | 576.62 |
分子式 | C30H31F3N8O |
CAS No. | T22597 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: ≥57.7mg/mL
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Bafetinib (INNO-406) T22597 Others Bafetinib (INNO 406) INNO 406 Bafetinib Bafetinib (INNO406) INNO406 INNO-406 Inhibitor inhibitor inhibit