Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Azido-PEG4-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
产品描述 | Azido-PEG4-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. |
体外活性 | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
分子量 | 219.24 |
分子式 | C8H17N3O4 |
CAS No. | 86770-67-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (456.12 mM)
H2O: 100 mg/mL (456.12 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O | 1 mM | 4.5612 mL | 22.8061 mL | 45.6121 mL | 114.0303 mL |
5 mM | 0.9122 mL | 4.5612 mL | 9.1224 mL | 22.8061 mL | |
10 mM | 0.4561 mL | 2.2806 mL | 4.5612 mL | 11.403 mL | |
20 mM | 0.2281 mL | 1.1403 mL | 2.2806 mL | 5.7015 mL | |
50 mM | 0.0912 mL | 0.4561 mL | 0.9122 mL | 2.2806 mL | |
100 mM | 0.0456 mL | 0.2281 mL | 0.4561 mL | 1.1403 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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