Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AP-III-a4 hydrochloride (ENOblock hydrochloride) is a novel small molecule which is the first, nonsubstrate analogue that directly binds to enolase and inhibits its activity (IC50=0.576 uM); inhibit cancer cell metastasis in vivo. IC50 value: 0.576 uM [1] Target: enolase Enolase is a component of the glycolysis pathway and a "moonlighting" protein, with important roles in diverse cellular processes that are not related to its function in glycolysis. However, small molecule tools to probe enolase function have been restricted to crystallography or enzymology. ENOblock is the first reported enolase inhibitor that is suitable for biological assays. This new chemical tool may also be suitable for further study as a cancer and diabetes drug candidate.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 970 | 待询 | ||
5 mg | ¥ 1,820 | 待询 | ||
10 mg | ¥ 2,925 | 待询 | ||
25 mg | ¥ 5,985 | 待询 | ||
50 mg | ¥ 8,450 | 待询 | ||
100 mg | 待询 | 待询 | ||
200 mg | 待询 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,515 | 待询 |
AP-III-a4 hydrochloride (1177827-73-4 free base) 的其他形式现货产品:
产品描述 | AP-III-a4 hydrochloride (ENOblock hydrochloride) is a novel small molecule which is the first, nonsubstrate analogue that directly binds to enolase and inhibits its activity (IC50=0.576 uM); inhibit cancer cell metastasis in vivo. IC50 value: 0.576 uM [1] Target: enolase Enolase is a component of the glycolysis pathway and a "moonlighting" protein, with important roles in diverse cellular processes that are not related to its function in glycolysis. However, small molecule tools to probe enolase function have been restricted to crystallography or enzymology. ENOblock is the first reported enolase inhibitor that is suitable for biological assays. This new chemical tool may also be suitable for further study as a cancer and diabetes drug candidate. |
别名 | ENOblock hydrochloride, AP-III-a4 hydrochloride |
分子量 | 631.18 |
分子式 | C31H44ClFN8O3 |
CAS No. | T6759L |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 53 mg/mL (83.97 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.5843 mL | 7.9217 mL | 15.8433 mL | 39.6084 mL |
5 mM | 0.3169 mL | 1.5843 mL | 3.1687 mL | 7.9217 mL | |
10 mM | 0.1584 mL | 0.7922 mL | 1.5843 mL | 3.9608 mL | |
20 mM | 0.0792 mL | 0.3961 mL | 0.7922 mL | 1.9804 mL | |
50 mM | 0.0317 mL | 0.1584 mL | 0.3169 mL | 0.7922 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
AP-III-a4 hydrochloride (1177827-73-4 free base) T6759L Others AP-III-a4 Hydrochloride 1177827-73-4 AP-III-a-4 hydrochloride (1177827-73-4 free base) APIIIa4 hydrochloride (1177827734 free base) ENOblock hydrochloride ENOblock Hydrochloride AP III a4 hydrochloride (1177827 73 4 free base) 1177827-73-4 free base AP-III-a4 hydrochloride Inhibitor inhibitor inhibit