keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AMY-101 TFA (Cp40 TFA) is a peptidic inhibitor of the central complement component C3 (KD: 0.5 nM). AMY-101 TFA shows a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation.
产品描述 | AMY-101 TFA (Cp40 TFA) is a peptidic inhibitor of the central complement component C3 (KD: 0.5 nM). AMY-101 TFA shows a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation. |
靶点活性 | C3:(kd)0.5 nM |
体内活性 | AMY-101 can induce a long-lasting anti-inflammatory effect. AMY-101 (4 mg/kg body weight, subcutaneous injection. once per 24 hr for a total of 28 days) causes a significant and long-lasting reduction in PPD [1]. |
动物实验 | Animal Model: Fifteen adult male cynomolgus monkeys (7–15 years old; 5.0–7.6 kg). Dosage: 0.1 mg/site; 50 μL of 2 mg/mL solution. Administration: Injected locally (Either three times per week or once a week for 6 weeks followed by a 6-week follow-up period without treatment) [1]. |
别名 | Cp40 TFA |
分子量 | 1903.14 |
分子式 | C85H118F3N23O20S2 |
CAS No. | 1789738-04-0 |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
AMY-101 TFA 1789738-04-0 Others AMY 101 TFA AMY101 TFA Cp40 TFA Inhibitor inhibitor inhibit