Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ALK5 Inhibitor II is an ALK5 inhibitor. IC50: 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 577 | 35日内发货 | ||
5 mg | ¥ 1,130 | 35日内发货 | ||
10 mg | ¥ 1,960 | 35日内发货 | ||
25 mg | ¥ 4,160 | 35日内发货 |
ALK5 Inhibitor II (hydrochloride) 的其他形式现货产品:
产品描述 | ALK5 Inhibitor II is an ALK5 inhibitor. IC50: 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively. |
体外活性 | In vitro: ALK5 inhibitor II was identified as a cell-permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5. ALK5 inhibitor II showed less potent activity (IC50s > 16 μM) when tested against a panel of 9 related kinases, including p38 MAPK and GSK3. In addition, when cocrystallized with ALK5, ALK5 inhibitor II was found to be able to bind in the ATP site with the 1,5-naphthyridine N5 interacting with the backbone NH of His-283 [1]. |
分子量 | 323.8 |
分子式 | C17H13N5·HCl |
CAS No. | 2319939-07-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: ≤0.5mg/ml
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
ALK5 Inhibitor II (hydrochloride) 2319939-07-4 Others ALK5 Inhibitor II ALK-5 Inhibitor II (hydrochloride) Inhibitor inhibitor inhibit