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7α-Hydroxy-4-cholesten-3-one

产品编号 T10196 CAS 3862-25-7

7α-Hydroxy-4-cholesten-3-one is an intermediate in the synthesis of bile acids from cholesterol. It is a PXR agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss and other diseases associated with defective bile acid biosynthesis.It is the physiological substrate for CYP8B1.

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7α-Hydroxy-4-cholesten-3-one Chemical Structure

7α-Hydroxy-4-cholesten-3-one, CAS 3862-25-7

规格	价格/CNY		货期	数量
1 mg	￥ 5,510		35日内发货

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述	7α-Hydroxy-4-cholesten-3-one is an intermediate in the synthesis of bile acids from cholesterol. It is a PXR agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss and other diseases associated with defective bile acid biosynthesis.It is the physiological substrate for CYP8B1.
体外活性	7α-Hydroxy-4-cholesten-3-one is found relatively upstream in the biosynthetic pathway to bile acids. The first step is the incorporation of the 7α-hydroxy group onto cholesterol by cytochrome P450 7A1, and the second step is the oxidation and isomerization of the 3-hydroxy group and the Δ5,6-double bond by a 3β-hydroxysteroid dehydrogenase to yield 7α-Hydroxy-4-cholesten-3-one. The deletion of the gene that expresses P450 27A1, which is found downstream in the bile acid pathway, results in the accumulation of the precursor, 7α-Hydroxy-4-cholesten-3-one [1].
体内活性	7α-Hydroxy-4-cholesten-3-one strongly relates to the hepatic enzymatic activity of CYP7A1 at steady-state conditions as well as during the rapid diurnal changes that occur in the rat. That serum 7α-Hydroxy-4-cholesten-3-one has a pronounced diurnal rhythm [2].

分子量	400.64
分子式	C27H44O2
CAS No.	3862-25-7

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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参考文献

1. Offei SD, et al. Chemical synthesis of 7α-hydroxycholest-4-en-3-one, a biomarker for irritable bowel syndrome and bile acid malabsorption. Steroids. 2019 Nov;151:108449. 2. Gälman C, et al. Bile acid synthesis in humans has a rapid diurnal variation that is asynchronous with cholesterol synthesis. Gastroenterology. 2005 Nov;129(5):1445-53.

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