Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(S,R,S)-AHPC-Me dihydrochloride, also known as VHL ligand 2 dihydrochloride, is a chemical compound utilized in the synthesis of ARV-771. ARV-771, a BET PROTAC degrader relying on von Hippel-Landau (VHL) E3 ligase, demonstrates potent degradation of BET protein in castration-resistant prostate cancer (CRPC) cells, with a DC50 of less than 1 nM. This compound serves as the VHL ligand, specifically the (S,R,S)-AHPC-based VHL ligand, that facilitates the recruitment of von Hippel-Lindau (VHL) protein.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 122 | 5日内发货 | ||
10 mg | ¥ 158 | 5日内发货 | ||
25 mg | ¥ 239 | 5日内发货 | ||
50 mg | ¥ 338 | 5日内发货 | ||
100 mg | 待询 | 5日内发货 |
(S,R,S)-AHPC-Me dihydrochloride 的其他形式现货产品:
产品描述 | (S,R,S)-AHPC-Me dihydrochloride, also known as VHL ligand 2 dihydrochloride, is a chemical compound utilized in the synthesis of ARV-771. ARV-771, a BET PROTAC degrader relying on von Hippel-Landau (VHL) E3 ligase, demonstrates potent degradation of BET protein in castration-resistant prostate cancer (CRPC) cells, with a DC50 of less than 1 nM. This compound serves as the VHL ligand, specifically the (S,R,S)-AHPC-based VHL ligand, that facilitates the recruitment of von Hippel-Lindau (VHL) protein. |
别名 | VHL ligand 2 dihydrochloride, E3 ligase Ligand 1 dihydrochloride, (S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base) |
分子量 | 517.51 |
分子式 | C23H34Cl2N4O3S |
CAS No. | T13671L |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (193.23 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.9323 mL | 9.6616 mL | 19.3233 mL | 48.3082 mL |
5 mM | 0.3865 mL | 1.9323 mL | 3.8647 mL | 9.6616 mL | |
10 mM | 0.1932 mL | 0.9662 mL | 1.9323 mL | 4.8308 mL | |
20 mM | 0.0966 mL | 0.4831 mL | 0.9662 mL | 2.4154 mL | |
50 mM | 0.0386 mL | 0.1932 mL | 0.3865 mL | 0.9662 mL | |
100 mM | 0.0193 mL | 0.0966 mL | 0.1932 mL | 0.4831 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
(S,R,S)-AHPC-Me dihydrochloride T13671L Others 1948273-02-6 free base VHL ligand 2 dihydrochloride 1948273-02-6 E3 ligase Ligand 1 dihydrochloride E3 ligase Ligand 1 (S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base) AHPC-Me Dihydrochloride E3 ligase Ligand 1 Dihydrochloride (S,R,S)AHPCMe dihydrochloride VHL ligand 2 AHPC-Me VHL ligand 2 Dihydrochloride (S,R,S) AHPC Me dihydrochloride Inhibitor inhibitor inhibit