Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(R)-JNJ-31020028 is a high affinity, selective brain penetrant antagonist of neuropeptide Y Y2 receptor(pIC50 values of 8.07, 8.22 and 8.21 for human, rat, and mouse Y2 receptor, respectively).
产品描述 | (R)-JNJ-31020028 is a high affinity, selective brain penetrant antagonist of neuropeptide Y Y2 receptor(pIC50 values of 8.07, 8.22 and 8.21 for human, rat, and mouse Y2 receptor, respectively). |
靶点活性 | Y2 receptor (mouse):8.21(pIC50), Y2 receptor (human):8.07(pIC50), Y2 receptor (rat):8.22(pIC50) |
体内活性 | Chronic icv administration of (R)-JNJ-31020028 at 5.6 μg/day using osmotic Alzet pump resulted in a significant decreases number of grooming events[1]. (R)-JNJ-31020028 treatment shows the Cmax, Tmax , AUCinf, Vd, and t1/2 were 4.35 μM, 0.5 hours, 7.91 h μM and 0.83 hours, respectively. (R)-JNJ-31020028 has antidepressant like effects in the olfactory bulbectomized rat (OBX) model. [1]. |
分子量 | 565.68 |
分子式 | C34H36FN5O2 |
CAS No. | 1094873-17-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
(R)-JNJ-31020028 1094873-17-2 Others JNJ 31020028 (R) JNJ 31020028 JNJ31020028 (R)JNJ31020028 JNJ-31020028 Inhibitor inhibitor inhibit