PAFR

The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor. The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM][7] Its pathogenetic role in chronic kidney failure has also been reported recently.

Cat. No.	Product Name	CAS No.	Purity
TN3443	Aristolactam AII 化合物 TN3443	53948-07-5	98%
TN3443	Aristolactam AII has cytotoxic activity, it also shows platelet aggregation inhibitory activity.
TN5045	Spiradine F 化合物 TN5045	21040-64-2	98%
TN5045	Spiradine F can significantly inhibit platelet-activating factor(PAF)-induced platelet aggregation in a concentration-dependent manner.
TN1815	Kadsulignan L 南五味子木脂素L	163660-06-8	98%
TN1815	Kadsulignan L shows in vitro antiviral effects on hepatitis B virus. It also shows moderate platelet-activating factor (PAF) antagonistic activities with the IC5...
TN4088	Futoenone 化合物 TN4088	19913-01-0	98%
TN4088	Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicate...
TN3520	Bisdethiobis(methylthio)gliotoxin 化合物 TN3520	74149-38-5	98%
TN3520	Bisdethiobis(methylthio)gliotoxin is a platelet activating factor (PAF) antagonist.
TN4181	Hancinone C 化合物 TN4181	111843-10-8	98%
TN4181	Hancinone C shows inhibitory activity against the platelet aggregation caused by PAF.
TN4660	Niranthin 珠子草素	50656-77-4	99.8%
TN4660	Niranthin 是一种木脂素，具有广泛的药理活性。它是L. donovaniIB 拓扑异构酶的非竞争性抑制剂，可用于研究耐药利什曼病的治疗。
T2751	Ginkgolide B 银杏内酯B	15291-77-7	99.77%
T2751	Ginkgolide B (BN-52021) 是一种萜类物质，是银杏叶中的重要的活性物质之一。
TN2329	Zingiberen newsaponin 盾叶新苷	91653-50-8	99.75%
TN2329	Zingiberen newsaponin 是分离自盾叶薯 (Dioscorea zingiberensis) 中。它能够诱导血小板聚集。
T6242	Rupatadine Fumarate 富马酸卢帕他定	182349-12-8	99.64%
T6242	Rupatadine Fumarate (Rinialer) 是一种可口服的长效PAF/H1受体的双抑制剂，Ki 值分别为 0.55 μM 和 0.1 μM。它可研究过敏性鼻炎和荨麻疹。
TN1643	Ferulamide 阿魏酸酰胺	61012-31-5	99.45%
TN1643	Ferulamide (4-Hydroxy-3-methoxycinnamide) 是从巴豆中分离的阿魏酸衍生物，具有抗胆碱酯酶活性。
T10159	48740 RP 化合物48740 RP	93363-11-2	99.4%
T10159	48740 RP (RP 55779) 是血小板活化因子的拮抗剂。
T17178	Tulopafant 妥洛帕泛	116289-53-3	99.38%
T17178	Tulopafant（RP 59227）是一种有效的血小板活化因子 (PAF) 拮抗剂，可增加毛细血管通畅性并延长异体心脏移植的生存期。
TN1271	Scutellarein tetramethyl ether 黄芩四甲基醚	1168-42-9	98.43%
TN1271	Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) 从暹罗草中提取，通过 NF-κB 途径表现出抗炎活性。
T14007	PAF-AN-1 PAF拮抗剂1	115621-84-6	98.06%
T14007	PAF-AN-1是一种新型有效的血小板激活因子受体 (PAF) 拮抗剂，参与研究过敏性死亡。
TN2322	Yangambin 鹅掌楸树脂酚B二甲醚	13060-14-5	98.02%
TN2322	Yangambin 是从诸如番荔枝科植物中分离出来的呋喃木脂素，是选择性PAF 受体拮抗剂，通过调控Ca2+通道抑制 Ca2+流入，导致 [Ca2+]i 在血管平滑肌细胞和随后的外周血管舒张中减少，具有降压作用。
TN3831	(-)-Denudatin B 化合物Denudatin B	87402-88-8	97.45%
TN3831	(-)-Denudatin B (Denudatin B) 源自 Magnolia fargesii。 (-)-Denudatin B 通过抑制胶原蛋白和凝血酶诱导的磷酸肌醇分解，在高浓度下具有非特异性抗血小板作用。