NOS

Nitric oxide synthases(NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS).

Cat. No.	Product Name	CAS No.	Purity
TN3139	5α-Hydroxycostic acid 化合物 TN3139	132185-83-2	98%
TN3139	5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
TN3805	Dehydrogeijerin 化合物 TN3805	16850-91-2	98%
TN3805	Dehydrogeijerin significantly inhibits the inflammatory activity of activated macrophages, suggesting that it could be a potential candidate for the treatment of...
TN3482	Bakkenolide B 化合物 TN3482	18455-98-6	98%
TN3482	Bakkenolide B has suppressive properties for allergic and inflammatory responses and may be utilized as a potent agent for the treatment of asthma.
TN2327	Zedoarondiol 化合物Zedoarondiol	98644-24-7	98%
TN2327	Zedoarondiol has anti-inflammatory activity, inhibits iNOS, COX-2, and pro-inflammatory cytokine expressions by suppressing the phosphorylations of IKK and MAPKs...
TN2534	1-Hydroxy-2,3,5-trimethoxyxanthone 化合物 TN2534	22804-49-5	98%
TN2534	1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independ...
TN4050	Fargesone A 化合物 TN4050	116424-69-2	98%
TN4050	Fargesone A shows inhibitory effects on nitric oxide (NO) production in the lipopolysaccharide plus interferon-gamma activated-murine macrophage cell line, J774....
TN4683	Nyasol 化合物 TN4683	96895-25-9	98%
TN4683	Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory ...
T22506	3,4-DAA 化合物 3,4-DAA	2117759-07-4	98%
T22506	3,4-DAA 具有抗炎活性，可改善急性肝同种异体移植损伤，通过抑制肠道屏障功能障碍和 NF-κB 活化来缓解严重的急性胰腺炎。3,4-DAA 抑制由 IFN-γ 和脂多糖诱导的 EOC20 细胞诱导型一氧化氮合酶 (iNOS) 发挥作用。
T7206	2-Iminobiotin 2-亚氨基生物素	13395-35-2	98%
T7206	2-Iminobiotin (Guanidinobiotin) 是一种生物素 (维生素 H 或 B7) 类似物。它是一种可逆的 NO 合酶抑制剂，能够作用于小鼠 iNOS(Ki:21.8 μM)及大鼠 n-cNOS(Ki:37.5 μM)。它和低温环境均可以保护人类神经细胞，使其免受缺氧诱导的细胞损伤。
TN4064	Flavoglaucin 化合物 TN4064	523-73-9	98%
TN4064	Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
TMA1409	Cis-Mulberroside A 化合物 TMA1409	166734-06-1	98%
TMA1409	cis-Mulberroside A shows high analgesic and anti-inflammatory activities, it can protect mice against ethanol-induced hepatic damage.
TN4286	Isodunnianol 化合物 TN4286	139726-30-0	98%
TN4286	Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM; it also exhibits neurite outgrowth-promoting activity at the concentration ranging from 0...
TN4602	Myricananin A 化合物 TN4602	1079941-35-7	98%
TN4602	Myricadenin A exhibits anti-inflammatory activities in the iNOS assay with EC50 values of 18.1 uM.
TN3539	Broussonin A 化合物 TN3539	73731-87-0	98%
TN3539	Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, tra...
TN3839	Desoxo-narchinol A 化合物 TN3839	53859-06-6	98%
TN3839	Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
TN5227	(+/-)-Vestitol 化合物 TN5227	56701-24-7	98%
TN5227	Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose and concentration and have a promising potential to...
TN2223	Soyacerebroside I 化合物Soyacerebroside I	114297-20-0	98%
TN2223	Soyacerebroside I demonstrates a potent tyrosinase inhibitory activity.
TN1598	Dunnianol 红花八角醇	139726-29-7	98%
TN1598	Dunnianol 显示出抗炎活性和适度的抗菌活性。
TN3966	Epicatechin pentaacetate 化合物 TN3966	20194-41-6	98%
TN3966	Epicatechin pentaacetate is a phenolic compound from the V. mullaha fruit extracts, the utilization of V. mullaha fruit as functional food with prospective pharm...
TN2775	2-Methoxystypandrone 化合物 TN2775	85122-21-0	98%
TN2775	2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-ÎºB signaling to limit the inflamm...