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4

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T35413	(6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride)
	(6R,S)-5,6,7,8-Tetrahydrofolic acid (THFA), the reduced form of folic acid, serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism. Its metabolites participate in the synthesis of thymidine for incorporation into DNA or the synthesis of purines, as well as in the formation of methionine, which can be converted to the ubiquitous methyl donor, S-adenosylmethionine . THFA has also been used to study the activation of metabolite-binding ribos...
T73731	10-Formyltetrahydrofolic acid disodium
	10-Formyltetrahydrofolic acid disodium 为四氢叶酸衍生物，作为甲酰基供体参与合成代谢。该化合物作为甲酰基转移酶反应底物，涉及嘌呤生物合成过程。
T60699	Aditoprime
	Aditoprime (Aditoprim) 是细菌二氢叶酸还原酶(DHFR)的选择性抑制剂。Aditoprime 抑制二氢叶酸向四氢叶酸的转化。Aditoprime 显示出良好的抗菌活性，具有广谱抗菌性，并且显示出良好的药代动力学。Aditoprime 抑制干酪乳杆菌和大肠杆菌 DHFR 的 IC50分别为520和47 nM。
T37998	N-(4-Aminobenzoyl)-L-glutamic Acid (hydrate)
	N-(4-Aminobenzoyl)-L-glutamic acid is an oxidation product and a metabolite of tetrahydrofolate.1Levels of N-(4-aminobenzoyl)-L-glutamic acid are increased in the plasma of mice fed a high folic acid-containing diet.2 1.Reed, L.S., and Archer, M.C.Oxidation of tetrahydrofolic acid by airJ. Agric. Food Chem.28(4)801-805(1980) 2.Burton, M.A., Antoun, E., Penailillo, R.S., et al.Folic acid induces intake-related changes in the mammary tissue transcriptome of C57BL/6 miceNutrients12(9)2821(2020)

化合物

(6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride)

Cat.No: T35413

10-Formyltetrahydrofolic acid disodium

Cat.No: T73731

Cat.No: T60699

N-(4-Aminobenzoyl)-L-glutamic Acid (hydrate)

Cat.No: T37998

Cat. No.	Product Name	Target	Signaling Pathways
T21367	Tetrahydrofolic acid 5,6,7,8-tetrahydrofolic acid,folate-H4,Tetrahydropteroylglutamic acid,th-folate	Endogenous Metabolite	Metabolism
	Tetrahydrofolic acid (5,6,7,8-tetrahydrofolic acid) 是一种维生素 B9 衍生物，是生物体常见的一碳供体，参与生物体生长代谢。
T7730	Aminopterin APGA,氨基蝶呤,4-Aminofolic acid	Antifolate	Cell Cycle/Checkpoint
	Aminopterin (4-Aminofolic acid) 是叶酸的 4-氨基衍生物，是叶酸拮抗剂，具有抗癌和免疫抑制活性，用于研究儿童白血病。它催化叶酸还原为四氢叶酸，竞争性抑制二氢叶酸还原酶，Ki 值为 3.7 pM。
T13516	5-Methyltetrahydrofolic acid 甲基叶酸盐,5-Methyl THF	Endogenous Metabolite	Metabolism
	5-Methyltetrahydrofolic acid (5-Methyl THF) 是四氢叶酸的甲基化衍生物，具有生物活性。5-Methyltetrahydrofolic acid 是主要的天然膳食叶酸，是血浆和脑脊液中叶酸的主要形式。
T15128	Dihydrofolic acid 7,8-Dihydrofolic acid,Dihydrofolate	Others	Others
	Dihydrofolic acid (7,8-Dihydrofolic acid) 是一种叶酸衍生物，在二氢叶酸还原酶的作用下生成四氢叶酸。

天然产物

Tetrahydrofolic acid

Cat.No: T21367

Synonym: 5,6,7,8-tetrahydrofolic acid,folate-H4,Tetrahydropteroylglutamic acid,th-folate

Target: Endogenous Metabolite

Cat.No: T7730

Synonym: APGA,氨基蝶呤,4-Aminofolic acid

Target: Antifolate

5-Methyltetrahydrofolic acid

Cat.No: T13516

Synonym: 甲基叶酸盐,5-Methyl THF

Target: Endogenous Metabolite

Dihydrofolic acid

Cat.No: T15128

Synonym: 7,8-Dihydrofolic acid,Dihydrofolate

Target: Others

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