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Search Results for " staphylococcal "

26

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1312	Nafcillin sodium monohydrate CL 8491,萘夫西林钠,nafcillin sodium	Antibacterial; Antibiotic	Microbiology/Virology
	Nafcillin sodium monohydrate (CL 8491) 是一种抗生素，是可逆的β-lactamase 抑制剂。它用于治疗由耐青霉素的葡萄球菌菌株引起的感染。
T62665	Antistaphylococcal agent 2
	Antistaphylococcal agent 2 是一种抗葡萄球菌的治疗剂。
T61855	Antistaphylococcal agent 1
	Antistaphylococcal agent 1 是一种抗葡萄球菌的治疗剂。
T39886	Antistaphylococcal agent 3
	Antistaphylococcal agent 3 is an antistaphylococcal therapeutic agent.
TP1699L	SEB Domain 144-153 acetate(210229-94-0 free base)	Others	Others
	SEB Domain 144-153 acetate(210229-94-0 free base) 是葡萄球菌肠毒素 B 结构域氨基酸残基 163-172。它已被证明可抑制多种葡萄球菌肠毒素、SEA、SEE 和 TSST-1 的转胞吞作用。
T22297	Clindamycin hydrochloride monohydrate Clindamycin alcoholate	Antibiotic	Microbiology/Virology
	Clindamycin hydrochloride monohydrate（Clindamycin alcoholate）是一种口服蛋白质合成抑制剂，具有在金黄色葡萄球菌中以亚抑制浓度(sub-MICs)抑制毒力因子表达的能力。其抗性来源于50S核糖体亚基（23S rRNA）的抗生素结合位点通过酶促甲基化。此外，Clindamycin hydrochloride monohydrate能显著减少杀白细胞毒素（PVL）、毒性休克-葡萄球菌毒素（TSST-1）或α-溶血素（Hla）的产生。
T41142	EM 163	IL Receptor; p38 MAPK; MyD88	Immunology/Inflammation; MAPK
	EM 163是一种 TIR-TIR 相互作用抑制剂，它是MyD88蛋白的TIR（Toll/白细胞介素-1受体）结构域拟态。EM 163针对IL-1受体中的TIR 结构域，阻断与MyD88的相互作用。EM 163抑制葡萄球菌肠毒素B（SEB）引起的体内炎症细胞因子的产生。EM 163能保护小鼠免受SEB 冲击引起的死亡。在体外的大鼠海马神经元中，EM 163阻断p38的激活和IL-1β对化学诱导的长期电位（LTP）引发的蛋白质合成的抑制作用。
TP1699	SEB Domain (144-153) SEB Domain 144-153
	This peptide is Staphylococcal Enterotoxin B domain amino acid residue 163-172. It has been shown to inhibit transcytosis of multiple staphylococcal enterotoxins, SEA, SEE, and TSST-1.
T26093	Ristocetin Spontin
	Ristocetin is an antibiotic isolated from Amycolatopsis lurida that is previously used to the treatment of staphylococcal infections. It is no longer used clinically because it caused thrombocytopenia and platelet agglutination.
T27559	HT-61 HY-50A,HY50A,HY 50A
	HT-61, a pyrroloquinolone antibiotic, is used potentially for the treatment of staphylococcal infections.
T82893	Bevifimod PRTX-100
	Bevifimod (PRTX-100)，一种高度纯化的葡萄球菌蛋白A (SpA)，主要用于特发性血小板减少性紫癜(ITP)的研究。
TP2163	SEB Domain 144-153 TFA(210229-94-0 free base) SEB Domain (144-153) (TFA)	Others	Others
	SEB Domain 144-153 TFA is Staphylococcal Enterotoxin B domain amino acid residue 144-153. It inhibits transcytosis of multiple staphylococcal enterotoxins, SEE, SEA, and TSST-1.
T25027	Albocycline TA-2407,Ingramycin
	Albocycline is a Macrolide antibiotic from Streptomyces bruneogriseus nov. sp. MCRL-0129; specifically anti-staphylococcal, including antibiotic-resistant strains.
T75294	Nafcillin sodium
	Nafcillin sodium 是一种抗生素，是可逆的β-lactamase 抑制剂。Nafcillin sodium 可用于葡萄球菌感染的研究。
T77215	Kanamycins sulfate
	Kanamycin sulfate，一种广谱性抗生素，适用于治疗严重的葡萄球菌或革兰氏阴性杆菌感染，但具有一定的耳毒性。
T76822	Pagibaximab
	Pagibaximab为一种嵌合IgG1抗体，针对金黄色葡萄球菌与表皮链球菌的表面脂肪酸成分具有特异性识别能力。其主要应用于预防葡萄球菌所引起的败血症。
T61274	PC190723
	PC190723 (Compound 2) 是一种细菌细胞分裂蛋白 FtsZ 抑制剂，IC50值为 55 ng/ml。FtsZ-IN-3 具有抗葡萄球菌活性，对 MSSA 和 MRSA 的MIC 值均为 1 μg/ml。
T76570	PSM-β
	PSM-β, 一种从表皮葡萄球菌中分离的活性肽，属于葡萄球菌毒素类似物，并且是酚溶性调节蛋白。该化合物展现出抑菌作用和低溶血性。
TP1583	HER2/neu (654-662) GP2
	Affibody (affibody) ligands that are specific for the extracellular domain of human epidermal growth factor receptor 2 (HER2/neu) have been selected by phage display technology from a combinatorial protein library based on the 58 amino acid residue staphy
T63370	FtsZ-IN-2
	FtsZ-IN-2 是细菌细胞分裂蛋白 FtsZ 抑制剂，对 GTPase 的活性具有抑制作用。FtsZ-IN-2 表现出抗葡萄球菌作用，对 MSSA 和 MRSA 的MIC 值均为 2 μg/ml。
T19678	Cefaloridine Cephaloridine,Sch 11527
	Cefaloridine is a first-generation semisynthetic derivative of cephalosporin C. It is unique among cephalosporins in that it exists as a zwitterion. Cephaloridine was very effective to cure pneumococcal pneumonia. It has a high clinical and bacteriologica
T79409	Antibacterial agent 154
	Antibacterialagent 154（compound 7）作为Fluoroquinolones类衍生物，适用于口服的抗菌治疗。它针对革兰氏阳性菌与阴性菌具有抑制作用，并在小鼠葡萄球菌败血症模型中显示出了体内效力。
T77111	Omodenbamab
	Omodenbamab 是一种抗 SpA(葡萄球菌蛋白 A) 人源化单克隆抗体，KD 值为 0.0467 nM。Omodenbamab 通过靶向细胞壁部分蛋白 A (SpA) 来规避关键的 S. aureus 逃避机制。Omodenbamab 可用于 S. aureus 血流感染的研究。
T74803	Levonadifloxacin
	Levonadifloxacin ((S)-(-)-Nadifloxacin; WCK 771)，作为一种宽谱抗葡萄球菌药物，对甲氧西林敏感金黄色葡萄球菌(MSSA)及对甲氧西林耐药金黄色葡萄球菌(MRSA)显示出显著的抗菌活性，并能有效减少THP-1单核细胞对MRSA和MSSA菌株的吞噬。
T73824	Thymidine 3',5'-diphosphate tetrasodium
	Thymidine 3',5'-diphosphate (Deoxythymidine 3′,5′-diphosphate) tetrasodium，为一种选择性抑制剂，主要针对葡萄球菌核酸酶及含1的都铎结构域(SND1，MicroRNA调控复合体RISC亚基)和[3,5-2H2]酪氨酸核酸酶([3,5-2H2] tyrosyl nuclease)。此化合物还展示了抗肿瘤活性，并可在生化反应中作为催化剂使用。
T38178	Ristocetin A (sulfate) Ristomycin III
	Ristocetin A, a glycopeptide related to vancomycin, is an antibiotic produced by the microorganism Nocardia lurida[1]. Ristocetin A is currently in clinical use to treat bacterial infections [1]. Ristocetin A is an antibiotic which can be used to treat staphylococcal infections. The side effects of ristocetin A include thrombocytopenia and platelet agglutination. Ristocetin A has been used in two assays: the ristocetin cofactor assay and the ristocetin-induced platelet aggregation assay. These t...

化合物

Nafcillin sodium monohydrate

Cat.No: T1312

Synonym: CL 8491,萘夫西林钠,nafcillin sodium

Target: Antibacterial, Antibiotic

Antistaphylococcal agent 2

Cat.No: T62665

Antistaphylococcal agent 1

Cat.No: T61855

Antistaphylococcal agent 3

Cat.No: T39886

SEB Domain 144-153 acetate(210229-94-0 free base)

Cat.No: TP1699L

Target: Others

Clindamycin hydrochloride monohydrate

Cat.No: T22297

Synonym: Clindamycin alcoholate

Target: Antibiotic

Cat.No: T41142

Target: IL Receptor, p38 MAPK, MyD88

SEB Domain (144-153)

Cat.No: TP1699

Synonym: SEB Domain 144-153

Cat.No: T26093

Synonym: Spontin

Cat.No: T27559

Synonym: HY-50A,HY50A,HY 50A

Cat.No: T82893

Synonym: PRTX-100

SEB Domain 144-153 TFA(210229-94-0 free base)

Cat.No: TP2163

Synonym: SEB Domain (144-153) (TFA)

Target: Others

Cat.No: T25027

Synonym: TA-2407,Ingramycin

Nafcillin sodium

Cat.No: T75294

Kanamycins sulfate

Cat.No: T77215

Cat.No: T76822

Cat.No: T61274

Cat.No: T76570

HER2/neu (654-662) GP2

Cat.No: TP1583

Cat.No: T63370

Cat.No: T19678

Synonym: Cephaloridine,Sch 11527

Antibacterial agent 154

Cat.No: T79409

Cat.No: T77111

Levonadifloxacin

Cat.No: T74803

Thymidine 3',5'-diphosphate tetrasodium

Cat.No: T73824

Ristocetin A (sulfate)

Cat.No: T38178

Synonym: Ristomycin III

Cat. No.	Product Name	Target	Signaling Pathways
T1235	Lincomycin hydrochloride monohydrate 洁霉素盐酸盐,林可霉素,Lincomycin hydrochloride hydrate	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Lincomycin hydrochloride monohydrate (Lincomycin hydrochloride hydrate) 是一种窄谱抗生素, 具有与红霉素相似的效力, 对革兰氏阳性球菌的作用效果很好, 主要抑制细菌细胞蛋白质的合成。
TN1165	(Rac)-Myrislignan 1-(3,4-dimethoxyphenyl)-2-(4-allly-2,6-dimethoxyphenoxy)propan-1-ol,rac-myrislignan,ALPHA-[1-[2,6-二甲氧基-4-(2-丙烯-1-基)苯氧基]乙基]-4-羟	Others	Others
	1-(3,4-Dimethoxyphenyl)-2-(4-allly-2,6-dimethoxyphenoxy)propan-1-ol shows anti-staphylococcal activity against a total of five multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus strains and the minimum inhibitory concentrations (MIC

天然产物

Lincomycin hydrochloride monohydrate

Cat.No: T1235

Synonym: 洁霉素盐酸盐,林可霉素,Lincomycin hydrochloride hydrate

Target: ribosome, Antibacterial, Antibiotic

(Rac)-Myrislignan

Cat.No: TN1165

Synonym: 1-(3,4-dimethoxyphenyl)-2-(4-allly-2,6-dimethoxyphenoxy)propan-1-ol,rac-myrislignan,ALPHA-[1-[2,6-二甲氧基-4-(2-丙烯-1-基)苯氧基]乙基]-4-羟

Target: Others

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