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Cat. No.	Product Name	Target	Signaling Pathways
TP2207	Pasireotide Acetate	Somatostatin	GPCR/G Protein
	Pasireotide acetate 是长效的环己肽生长激素抑制素类似物，具有抗分泌、抗增殖和促凋亡活性。它可抑制 GH、IGF-I 和 ACTH 的分泌，可用于研究肢端肥大症和库欣病。它还可以提高生长抑素受体的激动剂活性，对sst1、2、3、4、5的pKi 分别为 8.2、9.0、9.1、小于7.0 和 9.9。
TP1570L	Cortistatin-14 acetate Cortistatin-14 acetate(186901-48-4 Free base)	Somatostatin	GPCR/G Protein
	Cortistatin-14 acetate 是一种与生长抑素-14结构相似的神经肽，通过生长抑素受体 (sst1-sst5) 结合并发挥作用。Cortistatin-14 acetate 具有抗惊厥、神经保护作用和显著的抗炎作用。
TP1346	CYN 154806 TFA CYN 154806 TFA	Somatostatin	GPCR/G Protein
	CYN 154806 TFA(183658-72-2 free base) 是一种环状八肽，是一种有效的选择性生长抑素 sst2 受体拮抗剂。对于重组 sst2、sst1、sst3、sst4 和 sst5 受体，pIC50 值分别为 8.58、5.41、6.07、5.76 和 6.48。
TP1570	Cortistatin-14
	Cortistatin 14 is a neuropeptide expressed in inhibitory neurons of the cerebral cortex. Depresses neuronal activity, and induces slow-wave sleep, likely through antagonism of acetylcholine. It is structurally and functionally similar to somatostatin 14.
T23479	TT 232	Others	Others
	sst1/sst4 somatostatin receptors agonist
TP2045	CH 275
	Potent somatostatin receptor 1 (sst1) agonist; displays selectivity for sst1 (IC50 values are 30.9 nM, 345 nM, > 1 μM, > 10 μM and > 10μM for human sst1, sst3, sst4, sst2 and sst5 respectively). Attenuates somatostatin release in the rat nucleus accumbens
T12368	Pasireotide L-aspartate salt 帕瑞肽天门冬氨酸盐,SOM230 L-aspartate	Others	Others
	Pasireotide L-aspartate salt is a stable cyclohexapeptide somatostatin mimic that exhibits unique high-affinity binding to human somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9 respectively).
TP1877	CYN 154806
	CYN 154806 is a potent and selective somatostatin sst2 receptor antagonist, The pIC50 values are 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively.
T32511L	L-796,778 acetate L-796,778 acetate(217480-25-6 Free base)	Somatostatin	GPCR/G Protein
	L-796,778 acetate 是一种选择性生长抑素受体激动剂，对 sst3的IC50为24nM，对sst1、sst2、sst4和sst5的IC50大于1000nM。
T76034	Cortistatin-14 TFA
	Cortistatin-14 (TFA) 是一种神经肽，其结构与生长抑素-14相似，通过与生长抑素受体(sst1-sst5)结合来发挥效果。它具备抗惊厥、神经保护和显著抗炎作用。
T12370	Pasireotide SOM 230,SOM 320,帕瑞肽	Others	Others
	Pasireotide(SOM 230) is a stable cyclohexapeptide somatostatin mimic that exhibits unique high-affinity binding to human somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9 respectively).
TP2122	Seglitide
	Peptide agonist for sst2 and sst5 somatostatin receptors. IC50/Kd values (nM) at cloned human somatostatin receptors are: > 1000 (sst1), 0.2 - 1.5 (sst2), 27 - 36 (sst3), > 127 (sst4), and 0.06 - 23 (sst5).
T75248	Pasireotide (diaspartate)
	Pasireotide (SOM230) diaspartate 是一种长效的环己肽生长激素抑制素类似物，可以提高生长抑素受体的激动剂活性，对sst1/2/3/4/5的pKi 分别为 8.2/9.0/9.1/<7.0/9.9。Pasireotide diaspartate 具有抗分泌、抗增殖和促凋亡活性。
T28851	SRA880 free base SRA 880,NVPSRA880,NVP SRA880,NVP-SRA880,SRA-880,SRA880
	SRA880 is a non-peptide antagonist of somatostatin sst1-receptor. SRA880 displayed significantly lower affinity for the other human recombinant somatostatin receptors ( pK(d) < or = 6.0). SRA880 shows a certain binding affinity to the human dopamine D4 re
T35663	Cortistatin-29 (rat) (trifluoroacetate salt)
	Cortistatin-29 is a neuropeptide that is structurally similar to somatostatin-28. It is produced by cleavage of preprocortistatin to procortistatin, which is cleaved at dibasic amino acids to form cortistatin-29 and cortistatin-14 as well as other partial cleavage products. Cortistatin mRNA is expressed in the human brain and in interneurons of the rat hippocampus and cerebral cortex. Cortistatin-29 binds to somatostatin (SST) receptors with IC50 values of 2.8, 7.1, 0.2, 3, and 13.7 nM for SST1-...
T76596	PRL 3195
	PRL 3195 是一种somatostatin receptor 拮抗剂，对人生长抑素受体 sst5、sst2、sst3、sst1和 sst4的Ki 分别为 6、17、66、1000 和 1000 nM。
T11800	L-803087	Somatostatin	GPCR/G Protein
	L-803087 是一种具有高效性和选择性的生长抑素 sst4 受体激动剂，对 sst4 的 Ki 值为 0.7 nM，比其他生长抑素受体的选择性高 280 倍以上。L-803087 在体外诱导 AMPA 介导的海马突触反应，在体内增加了海藻酸盐促使的小鼠癫痫发作。
T13811	Pasireotide ditrifluoroacetate SOM230 ditrifluoroacetate,Pasireotide ditrifluoroacetate (396091-73-9 free base),Pasireotide TFA salt	Others	Others
	Pasireotide is a stable cyclohexapeptide somatostatin mimic.
T12369	Pasireotide pamoate SOM230 pamoate	Others	Others
	Pasireotide pamoate is a stable cyclohexapeptide somatostatin mimic. Pasireotide pamoate exhibits antisecretory, antiproliferative, and proapoptotic activity.
T39207	L-803087 TFA
	L-803087 TFA is a highly potent and selective agonist of the somatostatin sst4 receptor, exhibiting a Ki value of 0.7 nM. It displays a remarkable selectivity, being over 280-fold more preferential for the sst4 receptor compared to other somatostatin receptors. Furthermore, L-803087 TFA promotes AMPA-mediated synaptic responses in hippocampal preparations and enhances kainate-induced seizures in mice.

化合物

Pasireotide Acetate

Cat.No: TP2207

Target: Somatostatin

Cortistatin-14 acetate

Cat.No: TP1570L

Synonym: Cortistatin-14 acetate(186901-48-4 Free base)

Target: Somatostatin

Cat.No: TP1346

Synonym: CYN 154806 TFA

Target: Somatostatin

Cat.No: TP1570

Cat.No: T23479

Target: Others

Cat.No: TP2045

Pasireotide L-aspartate salt

Cat.No: T12368

Synonym: 帕瑞肽天门冬氨酸盐,SOM230 L-aspartate

Target: Others

Cat.No: TP1877

L-796,778 acetate

Cat.No: T32511L

Synonym: L-796,778 acetate(217480-25-6 Free base)

Target: Somatostatin

Cortistatin-14 TFA

Cat.No: T76034

Cat.No: T12370

Synonym: SOM 230,SOM 320,帕瑞肽

Target: Others

Cat.No: TP2122

Pasireotide (diaspartate)

Cat.No: T75248

SRA880 free base

Cat.No: T28851

Synonym: SRA 880,NVPSRA880,NVP SRA880,NVP-SRA880,SRA-880,SRA880

Cortistatin-29 (rat) (trifluoroacetate salt)

Cat.No: T35663

Cat.No: T76596

Cat.No: T11800

Target: Somatostatin

Pasireotide ditrifluoroacetate

Cat.No: T13811

Synonym: SOM230 ditrifluoroacetate,Pasireotide ditrifluoroacetate (396091-73-9 free base),Pasireotide TFA salt

Target: Others

Pasireotide pamoate

Cat.No: T12369

Synonym: SOM230 pamoate

Target: Others

Cat.No: T39207

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