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5

抑制剂 & 化合物

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天然产物

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Cat. No. Product Name Target Signaling Pathways
T2112 Fexinidazole

非昔硝唑,HOE 239

Others; Parasite Microbiology/Virology; Others
Fexinidazole (HOE 239) 是具有口服活性的硝基咪唑抗锥虫药物。它显示出对布鲁氏杆菌亚种和菌株的杀锥虫活性,IC50值为 0.7-3.3 μM (0.2-0.9 μg/ml)。它具有用于因感染布鲁氏菌引起的人类昏睡病的潜力。
T33278 Melarsoprol

Melarsoprolum,RP 3854,RP3854,RP-3854

Melarsoprol, an organoarsenic compound, can be used to treat trypanosomiasis (human African sleeping sickness).
T71685 NEU-1953

NEU-1953 is a potential candidate for sleeping sickness.
T28011 Megazol

CL 64855,CL-64855,CL64855

Megazol is a nitroimidazole based drug that cures some protozoan infections. A study of nitroimidazoles found the drug extremely effective against T. cruzi and T. brucei which cause Chagas disease and African sleeping sickness, respectively.
T35904 O-11

O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killingTrypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50of less than 1 μM in a cell culture assay.1,2The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface gl...

化合物

Fexinidazole
Cat.No: T2112
Synonym: 非昔硝唑,HOE 239
Target: Others, Parasite
Melarsoprol
Cat.No: T33278
Synonym: Melarsoprolum,RP 3854,RP3854,RP-3854
Target:
NEU-1953
Cat.No: T71685
Synonym:
Target:
Megazol
Cat.No: T28011
Synonym: CL 64855,CL-64855,CL64855
Target:
O-11
Cat.No: T35904
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T7641 5-Hydroxytryptophol

5-羟基色醇

Endogenous Metabolite Metabolism
5-Hydroxytryptophol 是哺乳动物 5-羟色胺的代谢物,它被用作饮酒的生物标志物并可以导致昏睡病。
TN4519 Mesuaxanthone A

胡桐,海棠木

Others Others
Mesuaxanthone A and mesuaxanthone B are two yellow pigments.They produce varying degrees of C.N.S. depression characterised by ptosis, sedation, decreased spontaneous motor activity, loss of muscle tone, potentiation of pentobarbitone sleeping time and et

天然产物

5-Hydroxytryptophol
Cat.No: T7641
Synonym: 5-羟基色醇
Target: Endogenous Metabolite
Mesuaxanthone A
Cat.No: TN4519
Synonym: 胡桐,海棠木
Target: Others
TargetMol Loading
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