Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8146 |
Imidocarb dipropionate
二丙酸咪唑苯脲,二丙酸双咪苯脲 |
Antibiotic; Parasite | Microbiology/Virology |
Imidocarb dipropionate 是一种抗原虫剂,对寄生虫 B. bovis 的 IC50为 87 μg/mL。 | |||
T37514 |
Hydroxy Dimetridazole
|
Drug Metabolite | Metabolism |
Hydroxy Dimetridazole 是Dimetridazol 的羟基化代谢产物。Dimetridazol 是一种硝基咪唑类药物,可用于对抗原生动物感染。 | |||
T0874 |
Dimetridazole
1, 2-Dimethyl-5-nitroimidazole,1,2-Dimethyl-5-nitroimidazole,二甲硝咪唑 |
Antibiotic; Parasite | Microbiology/Virology |
Dimetridazole (1, 2-Dimethyl-5-nitroimidazole) 是一种对抗原生动物感染的硝基咪唑类药物。 | |||
T0066 |
Dichlorophen
双氯酚,DDM,Dichlorophene |
Antibacterial; Parasite; Antifungal | Microbiology/Virology |
Dichlorophen (DDM) 是一种抗微生物剂,对绦虫,原生动物,真菌和细菌具有活性,通过增加肠道内容物的清除,消除肠道中的绦虫感染。 | |||
T17164 |
Trimetrexate
三甲曲沙,CI-898 |
Others | Others |
Trimetrexate is an effective competitive inhibitor of bacterial, protozoan, and mammalian dihydrofolate reductase. | |||
T28011 |
Megazol
CL 64855,CL-64855,CL64855 |
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Megazol is a nitroimidazole based drug that cures some protozoan infections. A study of nitroimidazoles found the drug extremely effective against T. cruzi and T. brucei which cause Chagas disease and African sleeping sickness, respectively. | |||
T70673 | NEU617 | ||
NEU617 is an inhibitor of the growth of protozoan parasites, against T. brucei bloodstream proliferation. | |||
T68611 | GW837016X | ||
GW837016X, also known as NEU-391, is a potent inhibitor of protozoan parasite proliferation. GW837016X extended life of treated mice by 50%, compared to untreated controls. At the cellular level, GW837016X inhibited mitosis and cytokinesis in T. brucei. | |||
T70753 |
PF00349412
|
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PF00349412 is a selective inhibitor of protozoan protein N-myristoyltransferases. Inhibition of N-myristoyltransferase has been validated pre-clin. as a target for the treatment of fungal and trypanosome infections, using species-specific inhibitors. | |||
T71917 |
FFK29
|
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FFK29 is a synthetic class II HDACi (Histone deacetylase inhibitors) which have have recently emerged as novel therapeutic options for treating various protozoan and parasitic diseases. While these HDACi demonstrated a negligible effect on the viability of mature cysts, Acanthamoeba encystation was significantly inhibited by these HDACi. In conclusion, these synthetic HDACi demonstrated potent amoebicidal effects and inhibited the growth and encystation of Acanthamoeba, thus highlighting their e... | |||
T25749 |
L-NIL dihydrochloride
L-NIL HCl,N-Iminoethyl-L-lysine dihydrochloride |
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L-NIL HCl is a relatively selective iNOS inhibitor (IC50s: 0.4-3.3, 8-38, and 17-92 µM for iNOS, eNOS, and nNOS). L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response | |||
T35904 |
O-11
|
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O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killingTrypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50of less than 1 μM in a cell culture assay.1,2The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface gl... |