Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T35648 |
4-Thiouridine
|
Others | Others |
4-Thiouridine (4-TU) 是一种光活化核糖核苷类似物,广泛用于RNA 分析。 | |||
T12006 |
Metarrestin
ML246 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Metarrestin (ML246) 是一种口服有效的选择性核仁周区室 (PNC) 抑制剂,可有效抑制转移。Metarrestin 破坏核仁结构并抑制 RNA 聚合酶 (Pol) I 转录,部分是通过与翻译延伸因子 eEF1A2 的相互作用。 | |||
T23802 |
BMH-22
BMH22 |
||
BMH-22 is an RNA polymerase I inhibitor that acts by causing nucleolar stress and showing potent anticancer activity across many tumor types. | |||
T23804 |
BMH-9
BMH 9 |
||
BMH-9 is an RNA polymerase I inhibitor that acts by causing nucleolar stress and showing potent anticancer activity across many tumor types. | |||
T23803 |
BMH-23
BMH23,BMH 23 |
||
BMH-23 is an RNA polymerase I inhibitor that acts by causing nucleolar stress and showing potent anticancer activity across many tumor types. | |||
T68859 |
Rudolfomycin
|
||
Rudolfomycin is a class II anthracycline antitumor antibiotic that inhibit the synthesis of nucleolar RNA in intact tumor cells. | |||
T73724 | WDR5-IN-4 TFA | ||
WDR5-IN-4 TFA 是一种染色质相关 WD 重复结构域 5 蛋白 (WDR5) 的 WIN 位点抑制剂,Kd 值为 0.1 nM。WDR5-IN-4 TFA 能够从染色质中取代 WDR5,并降低相关基因的表达,引起翻译抑制和核仁应激。具有抗癌作用。 | |||
T69908 |
Pidnarulex HCl
|
||
Pidnarulex HCl is the salt form of CX-5461, a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage. CX-5461 selectively inhibits rRNA synthesis by Pol I in the nucleolus, but does not inhibit mRNA synthesis by RNA Polymerase II (Pol II) and does not inhibit DNA replication or protein synthesis. Inhibition of Pol I results in nucleolar stress and release of ribosomal proteins (RP) from the nucleolus. T... |