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Cat. No.	Product Name	Target	Signaling Pathways
T21902	ML351	Lipoxygenase	Metabolism
	ML351 是一种高度特异的15-LOX-1抑制剂，其 IC50=200 nM。它对 T1D 非肥胖糖尿病小鼠模型的血糖异常和β细胞氧化应激有抑制作用。它对相关同工酶 (5-LOX、血小板 12-LOX、15-LOX-2、绵羊 COX-1 和人 COX-2) 表现出良好的选择性(>250倍)。
TP1679	BDC2.5 mimotope 1040-51
	BDC2.5 mimotope 1040-51 is a mimotope peptide for diabetogenic T cell clone BDC2.5. isolated from non-obese diabetic mice.This is a effectively agonistic peptide (mimotope) for diabetogenic T cell clone BDC2.5. from non-obese diabetic (NOD) mice. T cells
T82079	IGRP(206-214)
	IGRP(206-214) 是一种肽，具有生物活性。它对应于非肥胖糖尿病型(NOD)小鼠中胰岛特异性葡萄糖6磷酸酶催化亚基相关蛋白（IGRP）的206-214残基，并能诱导此类小鼠产生糖尿病。此外，该肽对胰岛素原特异性T细胞有着特定的作用。
T35622	FKGK 18
	FKGK 18 is an inhibitor of group VIA (GVIA) calcium-independent phospholipase A2 (iPLA2). It inhibits GVIA iPLA2 by 99.9% at 0.091 mole fraction in a mixed micelle activity assay and is selective for GVIA iPLA2 over GIVA cPLA2 and GV sPLA2 where it shows 80.8 and 36.8% inhibition, respectively. FKGK 18 inhibits iPLA2β activity in cytosolic extracts from INS-1 cells overexpressing iPLA2β (IC50 = ~50 nM) as well as iPLA2γ activity in mouse heart membrane fractions (IC50s = ~1-3 μM). It inhibits gl...
T82354	GAD65 (524-543)
	GAD65 (524-543) 是具有生物活性的肽，属于谷氨酸脱羧酶 65 (GAD65) 氨基酸片段 524-543。作为胰岛抗原的关键片段之一，该肽在自发性自身免疫性糖尿病非肥胖糖尿病 (NOD) 小鼠模型中，可诱导增殖性 T 细胞反应。GAD65 (524-543) 对T细胞克隆BDC2.5具有特异性刺激作用，但可能存在亲和力较低的问题。此外，p524-543免疫可增强NOD小鼠对通过BDC2.5 T细胞过继转移诱导的1型糖尿病的敏感性。
T35799	MBX-8025 (sodium salt)
	MBX-8025 is an agonist of peroxisome proliferator-activated receptor δ (PPARδ).1 It is greater than 750- and 2,500-fold selective for PPARδ over PPARα and PPARγ. MBX-8025 (10 mg/kg per day for eight weeks) reduces increases in fasting blood glucose and serum insulin levels, and decreases insulin resistance in Alms1 mutant (foz/foz) mice fed an atherogenic diet as a model of diet-induced obesity, type 2 diabetes, and non-alcoholic steatohepatitis (NASH).2 It also decreases serum alanine transamin...