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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T13486	Neurodegenerative Disorder-Targeting Compound 1	Others	Others
	Neurodegenerative Disorder-Targeting Compound 1 是一种靶向 calpain 的抑制剂。
T83527	(Rac)-Neurodegenerative Disorder-Targeting Compound 1
	(Rac)-Neurodegenerative Disorder-Targeting Compound 1为一种针对神经退行性疾病的化合物，具有calpain抑制活性。
T24265	KMS88009 KMS 88009,KMS-88009
	KMS88009 is an amyloid-β aggregation inhibitor that acts by ameliorating neurodegenerative disorder.
T61578	BRD3731
	BRD3731 is a selective inhibitor of GSK3β, demonstrating an IC50 value of 15 nM for GSK3β and 215 nM for GSK3α. Due to its inhibitory properties, BRD3731 holds promise for investigating various medical conditions, including post-traumatic stress disorder (PTSD), psychiatric disorders, diabetes, and neurodegenerative disorders [1].
T75751	β-Amyloid (1-40) (TFA)
	β-Amyloid (1-40) TFA 是阿尔茨海默症患者脑斑块中发现的一种主要蛋白片段。
T35804	C16 Lactosylceramide (d18:1/16:0)
	C16 Lactosylceramide is an endogenous bioactive sphingolipid. It forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors (GPCRs), suggesting a role in cell signaling. Plasma levels of C16 lactosylceramide are elevated in insulin-resistant cattle. C16 Lactosylceramide is also upregulated in a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder.
T35809	C20 Sphingomyelin (d18:1/20:0)
	C20 Sphingomyelin is a naturally occurring sphingolipid. Levels of C20 sphingomyelin are upregulated in the hippocampus of rats with diabetes induced by streptozotocin and in human plasma where it is positively correlated with insulin resistance in obese humans. C20 sphingomyelin is also upregulated in the liver of a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder. The plasma concentration of C20 sphingomyelin is decreased in m...
T73289	mHTT-IN-1
	mHTT-IN-1 (Example 1) 为针对突变亨廷顿蛋白 (mHTT) 的高效抑制剂，该蛋白具毒性，主导遗传性常染色体显性神经退行性疾病—亨廷顿氏病 (HD) 的发生。mHTT-IN-1 能有效降低 mHTT 水平，其 EC50 值为 0.46 nM。
T37191	Mu-6S-Palm-β-Glc
	Mu-6S-Palm-β-Glc is a fluorogenic substrate of palmitoyl-protein thioesterase (PPT, also known as CLN1), a lysosomal hydrolase that removes long-chain fatty acyl groups from modified cysteine residues in proteins. Mu-6S-Palm-β-Glc is cleaved by PPT/CLN1 to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM...

化合物

Neurodegenerative Disorder-Targeting Compound 1

Cat.No: T13486

Synonym:

Target: Others

(Rac)-Neurodegenerative Disorder-Targeting Compound 1

Synonym: KMS 88009,KMS-88009

β-Amyloid (1-40) (TFA)

Cat.No: T75751

Synonym:

Target:

C16 Lactosylceramide (d18:1/16:0)

Cat.No: T35804

Synonym:

Target:

C20 Sphingomyelin (d18:1/20:0)

Cat. No.	Product Name	Target	Signaling Pathways
T21883	Gedunin	HSP	Cytoskeletal Signaling; Metabolism
	Gedunin 是从印楝种子中提取的一种重要柠檬苦素，具有抗癌、抗病毒、抗炎和杀虫活性。它可阻断 SARS-CoV-2 病毒进入人宿主细胞，用于 COVID-19 研究。它是Hsp90抑制剂，诱导 Hsp90 依赖的蛋白降解，抑制卵巢癌细胞增殖。

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