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Search Results for " liposome "

19

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T19080	DOPE 1,2-二油酰-SN-甘油-3-磷酰乙醇胺	Others	Others
	DOPE (DOPE) 是一种阳离子脂质体的中性辅助脂质 (helper lipid)，能够与阳离子磷脂结合，增强裸 siRNA 的转染效率。
T19062	Sulforhodamine 101 磺基罗丹明101,磺基罗丹明 101,SR101	Others	Others
	Sulforhodamine 101 (SR101) 是一种两性罗丹明红色荧光染料 (excitation/emission: 586/605 nm)，常用于神经元形态的研究，并作为星形胶质细胞的细胞类型选择性荧光标记物，在体内和切片制备中都有应用。
T64561	DPhPC	Others	Others
	DPhPC 是一种用于合成脂质体，常用于人工膜基质。DPhPC 双层膜在没有孔/离子通道的情况下不允许离子泄漏。DPhPC可用于研究通道蛋白质和膜结构。
T8902	DOTMA Trimethyl[2,3-(dioleyloxy)propyl]ammonium Chloride,N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium	Others	Others
	DOTMA (N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium) 作为 tetra-methylated DOTA 类似物，是一种阳离子脂类，被用作基因治疗的非病毒载体。它已被用作脂质体的成分，可用于封装 siRNA、microRNA 和寡核苷酸，并用于体外基因转染。在体外和体内均表现出良好的基因转染效果。DOTMA 诱导脂质体上的正电荷，从而促进脂质体与细胞膜的有效相互作用。
T28117	MSN-50 MSN50,MSN 50
	MSN-50, an inhibitor of Bax and Bak oligomerization, inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection.
T74237	Dielaidoylphosphatidylethanolamine
	Dielaidoylphosphatidylethanolamine 是一种用于递送活性分子的脂质体。
T74286	18:1 Ethylene Glycol
	18:1 Ethylene Glycol 是一种用于递送活性分子的脂质体。
T38967	DSPE-PEG(2000)
	MPEG-2000-DSPE sodium is a phospholipid PEG conjugate with hydrophilicity and hydrophobicity. It is utilized in liposome synthesis to enhance the hydrophilicity of liposomes, thereby prolonging their circulation in the bloodstream. This compound is commonly employed for the investigation of anticancer and antimalarial agents.
T73741	CLinDMA
	CLinDMA 是一种阳离子脂质，可引起炎症反应。CLinDMA 可用于合成 LNP201。LNP201 是一种脂质体组件，用于 siRNA 的全身递送。
T81338	Pyrromethene 556 PM556
	Pyrromethene 556 (PM556) 是一种绿色荧光极性示踪染料。它应用于膜融合、溶解和隙缝连接通信的研究，以及探测细胞或脂质体体积变化。
T38679	DODAP
	DODAP, an ionizable cationic lipid, serves as a vital component in liposome formation. Its applications encompass the capability to encapsulate siRNA, immunostimulatory chemotherapeutic agents for in vitro and in vivo delivery, among others.
T74231	DMPE
	DMPE 是二肉豆蔻酰磷脂酰胆碱。DMPE 是一种用于递送活性分子的脂质体。
T74363	Chol-TPP
	Chol-TPP 是一个线粒体靶向脂质体配体，可用于 pH -氧化还原反应。
T77276	DOPE-mPEG (MW 2000)
	DOPE-mPEG (MW 2000)，一种磷脂多分散PEG（亦称DOPE脂质体），广泛应用于制备靶向给药脂质体及巨大单层囊泡(GUVs)。此化合物能显著降低脂质体对pH的敏感性，其作用具浓度依赖性。
T36322	C8 D-threo Ceramide (d18:1/8:0) C8 D-threo Ceramide (d18:1/8:0)
	C8 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 17 μM) and induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 ceramide . C8 D-threo Ceramide is a substrate for E. coli diacylglycerol kinase. It activates ceramide-activated protein kinase (CAPK) in U937 cells. C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein r...
T74568	Phospholipid-PEG-Biotin (MW 20000)
	Phospholipid-PEG-Biotin (MW 20000) 与 Phospholipid-PEG-Biotin (MW 3400) 均为磷脂和生物素通过线性 PEG 连接剂桥接形成的磷脂聚乙二醇衍生物。其中，Phospholipid-PEG-Biotin (MW 3400) 能与亲和抗体进行相互作用，并可用于修饰脂质体、细胞表面及胰岛细胞移植。
T37534	DMPAC-Chol
	DMPAC-Chol is a cationic cholesterol derivative that has been used in liposome formation for gene transfection. Liposomes containing DMPAC-chol bind to DNA in a band shift assay and protect against serum nuclease degradation of DNA when used at lipsome:DNA ratios ranging from 2.5:1 to 10:1 w/w. DMPAC-Chol-containing liposomes also reduce viability of HepG2 cells by 63% when used at a concentration of 37.5 μg/ml.
T74565	Phospholipid-PEG-Biotin (MW 3400)
	Phospholipid-PEG-Biotin (MW 3400) 为一种通过线性PEG链接剂桥接磷脂和生物素的磷脂聚乙二醇衍生物。该化合物能够与亲和抗体进行相互作用，并可用于脂质体及细胞表面的修饰，也适用于胰岛细胞移植。
T36324	C8 L-threo Ceramide (d18:1/8:0) C8 L-threo Ceramide (d18:1/8:0)
	C8 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 10 μM) and, like C8 D-threo ceramide , induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 L-erythro ceramide . C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein release, with a 50% release dose (RD50) value of ~30 μg/ml.

化合物

Cat.No: T19080

Synonym: 1,2-二油酰-SN-甘油-3-磷酰乙醇胺

Target: Others

Sulforhodamine 101

Cat.No: T19062

Synonym: 磺基罗丹明101,磺基罗丹明 101,SR101

Target: Others

Cat.No: T64561

Target: Others

Cat.No: T8902

Synonym: Trimethyl[2,3-(dioleyloxy)propyl]ammonium Chloride,N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium

Target: Others

Cat.No: T28117

Synonym: MSN50,MSN 50

Dielaidoylphosphatidylethanolamine

Cat.No: T74237

18:1 Ethylene Glycol

Cat.No: T74286

Cat.No: T38967

Cat.No: T73741

Pyrromethene 556

Cat.No: T81338

Synonym: PM556

Cat.No: T38679

Cat.No: T74231

Cat.No: T74363

DOPE-mPEG (MW 2000)

Cat.No: T77276

C8 D-threo Ceramide (d18:1/8:0)

Cat.No: T36322

Synonym: C8 D-threo Ceramide (d18:1/8:0)

Phospholipid-PEG-Biotin (MW 20000)

Cat.No: T74568

Cat.No: T37534

Phospholipid-PEG-Biotin (MW 3400)

Cat.No: T74565

C8 L-threo Ceramide (d18:1/8:0)

Cat.No: T36324

Synonym: C8 L-threo Ceramide (d18:1/8:0)

Cat. No.	Product Name	Target	Signaling Pathways
TN7229	Baihuaqianhuoside Praeroside	Others	Others
	Baihuaqianhuoside (Praeroside) 是一种香豆素苷。Baihuaqianhuoside 可以从西番莲和 Hindenia solanacea 的根部分离出来，是首次从 P. japonicum 身上分离出来的。Baihuaqianhuoside 在体外具有抗炎活性，可以用于炎症的研究。Baihuaqianhuoside 对1,1-二苯基-2-丙烯酰肼自由基的清除作用，以及对2,2'-偶氮双（2-脒基丙烷）二盐酸盐诱导的脂质体氧化的抑制作用。
TN5129	Tetrahydro tanshinone I	Others	Others
	Tetrahydro tanshinone I is one compound of Fufang Danshen Prescription (FDP) , liposome equilibrium dialysis system could simply and effectively esti-mate the absorption of multiple components in FDP in vivo, and predicts the potential bioactivity of thes

天然产物

Baihuaqianhuoside

Cat.No: TN7229

Synonym: Praeroside

Target: Others

Tetrahydro tanshinone I

Cat.No: TN5129

Target: Others

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