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Cat. No. | Product Name | Target | Signaling Pathways |
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T79733 | NLRP3-IN-20 | NOD-like Receptor (NLR) | Immunology/Inflammation |
NLRP3-IN-20(compound 11)是一款口服活性的NLRP3炎症小体抑制剂,其抑制IL-1β分泌的IC50值为25 nM。该化合物展现出卓越的药代动力学性质,并在非酒精性脂肪性肝炎、致命性感染性休克以及结肠炎模型中证明了其显著疗效。 | |||
T71910 |
Racemic rasagiline
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Racemic rasagiline,也称为 AGN-1135,是一种单胺氧化酶 B 型抑制剂(MAOI)。然而,在食用富含酪胺的食物的患者中,这种药物的应用可能导致致命的高血压危象。TVP-1022是雷沙吉兰的(S)异构体,具有心脏保护剂的作用。 | |||
T65440 | Sodium Thiosulfate Pentahydrate | ||
Sodium thiosulfate (Pentahydrate) is an antioxidant and antifungal. Sodium thiosulfate protects against cisplatin-induced hearing loss in children and is not associated with serious adverse events attributed to its use[3]. The addition of sodium thiosulfate, administered 6 hours after cisplatin chemotherapy, resulted in a lower incidence of cisplatin-induced hearing loss among children with standard-risk hepatoblastoma, without jeopardizing overall or event-free survival[4]. Calciphylaxis is a p... | |||
T37582 |
Ganglioside GM1 Mixture (ovine) (ammonium salt)
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Ganglioside GM1is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue.1,2It is found in a large variety of cells, including immune cells and neurons, and is enriched in lipid rafts in the cell membrane.3It associates with growth factor receptors, including TrkA, TrkB, and the GDNF receptor complex containing Ret and GFRα, and is required for TrkA expression on the cell surface. Ganglioside GM1interacts with other proteins to increase calcium i... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T7438 |
3,5-Dimethoxyphenol
Phloroglucinol dimethyl ether,3,5-二甲氧基苯酚 |
Tyrosinase | Proteases/Proteasome |
3,5-Dimethoxyphenol (Phloroglucinol dimethyl ether) 是一种存在于人类食用红豆杉的叶子中的毒素代谢物。 | |||
T1135 |
Vitamin D3
维生素D3,Cholecalciferol,Colecalciferol |
Endogenous Metabolite | Metabolism |
Vitamin D3 (Cholecalciferol) 是维生素 D 的一种天然存在形式,代谢激活后可以诱导细胞分化和癌细胞增殖。 | |||
T83597 |
(+)-Menthyl acetate
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(+)-Menthyl acetate是一种从Cunila angustifolia Benth精油中分离得到的化学化合物。它对MCF-7细胞株具有较高的选择性,其半抑制浓度(IC50)为34.0 μg/mL,而对SK-Mel-28细胞株的选择性较低,IC50为279.9 μg/mL,并且对A549细胞没有致死作用。 |