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Cat. No. Product Name Target Signaling Pathways
T6820 D-α-Hydroxyglutaric acid disodium

D-alpha-Hydroxyglutaric acid disodium salt,(R)-2-羟基戊二酸二钠盐,Disodium (R)-2-Hydroxyglutarate

ATPase; Others; Reactive Oxygen Species; Endogenous Metabolite; mTOR Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB; Others; PI3K/Akt/mTOR signaling
D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-Hydroxyglutarate) 是神经代谢疾病 D-2-羟基戊二酸尿症中积累的主要代谢产物,可增加活性氧的产生。它是 α-酮戊二酸 (α-KG) 的弱竞争拮抗剂,可抑制多种α-KG 依赖性双加氧酶,Ki 为 10.87 mM。
T37557 (-)-(α)-Kainic Acid (hydrate)

(-)-(α)-Kainic Acid (hydrate) 是一种有效的兴奋性毒性剂,可诱发癫痫发作。(-)-(α)-Kainic Acid (hydrate) 也是离子型谷氨酸受体亚型的激动剂。
T24787 SGE-201

SGE-201 is an allosteric modulator of N-methyl-D-aspartate receptors. SGE-201 also unmasked differences among the blockers in neuronal networks - measured either by suppression of activity in multi-electrode arrays or by neuroprotection against a mild exc
T37608 Riluzole-13C,15N2

Riluzole-13C,15N2

Riluzole-13C,15N2 is intended for use as an internal standard for the quantification of riluzole by GC- or LC-MS. Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM). Riluzole suppresses glutamate-induced seizures in rats at an ED50 value of 3.2 mg/kg and displays neuroprotective effects in hypoxic animals a...

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D-α-Hydroxyglutaric acid disodium
Cat.No: T6820
Synonym: D-alpha-Hydroxyglutaric acid disodium salt,(R)-2-羟基戊二酸二钠盐,Disodium (R)-2-Hydroxyglutarate
Target: ATPase, Others, Reactive Oxygen Species, Endogenous Metabolite, mTOR
(-)-(α)-Kainic Acid (hydrate)
Cat.No: T37557
Synonym:
Target:
SGE-201
Cat.No: T24787
Synonym:
Target:
Riluzole-13C,15N2
Cat.No: T37608
Synonym: Riluzole-13C,15N2
Target:
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