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17

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T41215	LC 2 Epimer
	Negative control for LC 2.
T71048	Tacrolimus anhydrous 8-epimer
	Tacrolimus anhydrous 8-epimer is a new l-pipecolic acid macrolide lactone, an important immunosuppressive drug that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2.
T26330	WIN 5063-3 WIN-5063-3,Thiamphenicol epimer,WIN5063-3,L-Thiamphenicol
	WIN 5063-3 is the enantiomeric analog of the antimicrobial Thiamphenicol.
T75390	Aldose 1-epimerase
	Aldose 1-epimerase (mutarotases) 是关键碳水化合物代谢酶，主要催化己糖如葡萄糖及半乳糖的α-与β-端基异构体互转。对于碳水化合物代谢及复杂寡糖生成至关重要。
T8339	16α-Hydroxyprednisolone 16alpha-羟基泼尼松龙,16alpha-Hydroxyprednisolone	Others; Drug Metabolite	Metabolism; Others
	16α-Hydroxyprednisolone 是糖皮质激素布地奈德 22(R) epimer 构型的代谢物，经过 CYP3A 酶代谢生成。
T19299	DTE Cleland’s reagent,Dithioerythritol	Others	Others
	Dithioerythritol (DTE), a sulfur-containing sugar derivative of the 4-carbon monosaccharide erythrose, is an epimer of dithiothreitol (DTT).
T10132	(3S,5S)-Pitavastatin calcium	Others	Others
	(3S,5S)-Pitavastatin calcium is the 3-epimer of Pitavastatin which is a potent HMG-CoA reductase inhibitor.
T36043	17(R)-Protectin D1 17(R)-Protectin D1
	17(R)-Protectin D1 is an aspirin-triggered epimer of the specialized pro-resolving mediator protectin D1 .1It decreases leukotriene B4-induced transendothelial migration of human polymorphonuclear (PMN) neutrophils when used at concentrations ranging from 0.1 to 10 nM. 17(R)-Protectin D1 (0.01-10 ng) reduces the recruitment of neutrophils in a mouse model of TNF-α-induced peritonitis. 1.Serhan, C.N., Fredman, G., Yang, R., et al.Novel proresolving aspirin-triggered DHA pathwayChem. Biol.18(18)97...
T35500	3-epi-25-hydroxy Vitamin D3 3-epi-25-hydroxy Vitamin D3
	3-epi-25-hydroxy Vitamin D3is the C-3 epimer of 25-hydroxy vitamin D3.1Dietary administration of 3-epi-25-hydroxy vitamin D3(0.5 and 1 IU/g) decreases levels of serum parathyroid hormone (PTH) in male, but not female, weanling rats. 1.Djekic-Ivankovic, M., Lavery, P., Agellon, S., et al.The C-3α epimer of 25-hydroxycholecalciferol from endogenous and exogenous sources supports normal growth and bone mineral density in weanling ratsJ. Nutr.147(2)141-151(2017)
T37001	7-epi Maresin 1
	7-epi Maresin 1 is the inactive 7(S) epimer of Maresin 1 , which contains a 7(R) hydroxyl group. It can be used as an experimental negative control.
T82805	Butaprost free acid
	(R)-Butaprost (free acid) 是PGE2的一个结构类似物，特异性地对EP2受体亚型有选择性。该化合物用于药理学研究，以确定不同人类及动物组织和细胞中EP受体的分布。去除甲酯基团并恢复C-1自然羧酸后，增强了(R)-butaprost与前列腺素受体的结合亲和力，通常情况下，游离酸形式的亲和力是相应酯形式的10到100倍。尽管(R)-butaprost作为C-16的较低活性差向异构体，其药理作用未经充分研究，但在1986年Gardiner的论文中提到的TR 4979即布他前列素，结构中的差向异构体错误表达为16(R)，实际为16(S)，该错误直至1990年代后期才被美国和日本的研究纠正。
T36595	4-epi-Chlortetracycline (hydrochloride)
	Chlortetracycline is an analog of tetracycline , a broad spectrum antibiotic. In addition to its actions against microorganisms, chlortetracycline suppresses inflammation by inhibiting neutrophil action and other aspects of the innate immune response. 4-epi-Chlortetracycline is an epimer of chlortetracycline.
T37965	4-Epitetracycline hydrochloride
	Epitetracycline is an epimer of the antibiotic tetracycline . Epimers of tetracycline form without catalysis and are considered degradation products. Epitetracycline has decreased activity as an antibiotic or a Tet repressor effector but may have stronger toxic effects in animals.
T36144	11β-Prostaglandin E2 11β-PGE2,11β-Prostaglandin E2
	11β-PGE2 is the C-11 epimer of PGE2. It is a moderate inhibitor of PGE2 binding to rat hypothalamic membranes with a Ki value of 53 nM.[1] 11β-PGE2 also stimulates bone resorption in rats at concentrations of 10-8 to 10-6 M which is similar to PGE2.2 11β-PGE2 inhibits PGE2 binding to the prostaglandin transporter protein with a Ki of 56 nM.[3] .
T37649	5(S),12(S)-DiHETE
	5(S),12(S)-DiHETE is a natural bioactive lipid derived from arachidonic acid . It is synthesized by glycogen-induced rabbit peritoneal polymorphonuclear leukocytes (PMNLs) incubated with AA. 5(S),12(S)-DiHETE can be produced by successive oxygenation of AA by 5-lipoxygenase (5-LO) in platelets and 12-LO in leukocytes. It can also be synthesized from 12(S)-HETE by 5-LO, in the presence of 5-LO activating protein (FLAP), activated with calcium ionophore. 5(S),12(S)-DiHETE is an epimer of leukotrie...
T36208	15(R)-Pinane Thromboxane A2 15(R)-Pinane Thromboxane A2
	15(R)-Pinane thromboxane A2 is the (R)-epimer of pinane thromboxane A2 . 15(R)-PTA2 does not inhibit collagen-induced platelet aggregation (IC50s = 120-130 μM). It does not affect gastric tone in isolated rat gastric fundus when used at concentrations of 0.5 or 1.5 μg/ml and is less effective than PTA2 at inhibiting prostaglandin-induced contraction of isolated rat stomach muscle.
T35946	17(R)-Resolvin D1 Aspirin-triggered Resolvin D1,17(R)-Resolvin D1
	Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.[1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.[2] Resolvin D1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.[1] 17(R)-RvD1 is an aspirin-triggered epimer of RvD1 that reduces human polymorphonuclear leukocyte (PMN) transendothelial migration, the ear...

化合物

Cat.No: T41215

Tacrolimus anhydrous 8-epimer

Cat.No: T71048

Cat.No: T26330

Synonym: WIN-5063-3,Thiamphenicol epimer,WIN5063-3,L-Thiamphenicol

Aldose 1-epimerase

Cat.No: T75390

16α-Hydroxyprednisolone

Cat.No: T8339

Synonym: 16alpha-羟基泼尼松龙,16alpha-Hydroxyprednisolone

Target: Others, Drug Metabolite

Cat.No: T19299

Synonym: Cleland’s reagent,Dithioerythritol

Target: Others

(3S,5S)-Pitavastatin calcium

Cat.No: T10132

Target: Others

17(R)-Protectin D1

Cat.No: T36043

Synonym: 17(R)-Protectin D1

3-epi-25-hydroxy Vitamin D3

Cat.No: T35500

Synonym: 3-epi-25-hydroxy Vitamin D3

7-epi Maresin 1

Cat.No: T37001

Butaprost free acid

Cat.No: T82805

4-epi-Chlortetracycline (hydrochloride)

Cat.No: T36595

4-Epitetracycline hydrochloride

Cat.No: T37965

11β-Prostaglandin E2

Cat.No: T36144

Synonym: 11β-PGE2,11β-Prostaglandin E2

5(S),12(S)-DiHETE

Cat.No: T37649

15(R)-Pinane Thromboxane A2

Cat.No: T36208

Synonym: 15(R)-Pinane Thromboxane A2

17(R)-Resolvin D1

Cat.No: T35946

Synonym: Aspirin-triggered Resolvin D1,17(R)-Resolvin D1

Cat. No.	Product Name	Target	Signaling Pathways
T3828	(-)-Gallocatechin (2S,3R)-gallocatechin,(−)-GC,(-)-棓儿茶酸；没食子儿茶素,没食子儿茶素	Others	Others
	(-)-Gallocatechin ((−)-GC) 是一种 (-)-Epigallocatechin (EGC) 的差向异构体，常存在于各种茶产品中，具有抗氧化特性。
T5915	D-chiro-Inositol D-手性肌醇,D-(+)-CHIRO-INOSITOL	Endogenous Metabolite	Metabolism
	D-chiro-Inositol (D-(+)-CHIRO-INOSITOL) 是肌醇差向异构体，存在于某些哺乳动物糖基磷脂酰肌醇蛋白锚和具有胰岛素样生物特性的肌醇磷脂聚糖中。它能够抑制高血糖，改善胰岛素抵抗。它用于多囊卵巢综合征和糖尿病的相关研究。
TN6799	Epiprogoitrin 表原告依春,epi-Progoitrin	Others	Others
	Epiprogoitrin (epi-Progoitrin) 是一种硫代葡萄糖苷，来自于Crambe abyssinica 种子。
T81318	R-30-Hydroxygambogic acid
	R-30-Hydroxygambogic acid是从藤黄提取的一种聚戊烯酰黄酮外聚体，对K562/R和K562/S两种人白血病细胞系的IC50分别为2.89 μM和1.27 μM。该化合物适用于癌症研究领域。
T81232	S-30-Hydroxygambogic acid
	S-30-Hydroxygambogic acid，一聚戊烯酰黄酮外聚体，源自藤黄。针对人白血病细胞系K562/R及K562/S，其IC50值别为4.49 μM与3.61 μM。S-30-Hydroxygambogic acid主用于癌症研究领域。
T75631	Ganorbiformin B
	Ganorbiformin B是一种具有与灵芝酸相同羊毛甾烷骨架的羊毛甾烷三萜类化合物。其C-3差向异构体灵芝酸T对结核分枝杆菌H37Ra显示出强抗分枝杆菌活性。

天然产物

(-)-Gallocatechin

Cat.No: T3828

Synonym: (2S,3R)-gallocatechin,(−)-GC,(-)-棓儿茶酸；没食子儿茶素,没食子儿茶素

Target: Others

D-chiro-Inositol

Cat.No: T5915

Synonym: D-手性肌醇,D-(+)-CHIRO-INOSITOL

Target: Endogenous Metabolite

Cat.No: TN6799

Synonym: 表原告依春,epi-Progoitrin

Target: Others

R-30-Hydroxygambogic acid

Cat.No: T81318

S-30-Hydroxygambogic acid

Cat.No: T81232

Ganorbiformin B

Cat.No: T75631

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