Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2345 |
PTC-209
PTC209,PTC 209 |
BMI-1; Autophagy | Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
PTC-209 是特定的BMI-1抑制剂,不可逆转地损害结直肠癌起始细胞,在 HEK293T 细胞系中的IC50为 0.5 μM。它有抗骨髓瘤活性并损害肿瘤微环境。 | |||
T6178 |
PTC-209 hydrobromide
PTC-209 HBr |
BMI-1; Autophagy | Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
PTC-209 hydrobromide (PTC-209 HBr) 是一种特定的BMI-1抑制剂,能不可逆转地损害结直肠癌起始细胞,也可损害肿瘤微环境,有抗骨髓瘤活性。它在 HEK293T 细胞系中的IC50为 0.5 μM。 | |||
T38637 |
Roy-Bz
|
||
Roy-Bz is a potent and selective activator of protein kinase C delta (PKCδ). It effectively inhibits proliferation in colon cancer cells by initiating a mitochondrial apoptotic pathway that relies on PKCδ and involves the activation of caspase-3. | |||
T36485 |
Becatecarin
|
||
Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin. It intercalates into DNA, stabilizing the DNA-topoisomerase complex. This results in the potent catalytic inhibition of both topoisomerases I and II, initiating DNA cleavage and apoptosis. Becatecarin, alone or in combination with other compounds, has anti-cancer as well as myelosuppressive effects in vivo. It is also a transport substrate of the ATP-binding cassette (ABC) transporter ABCG2. | |||
T35940 |
Darinaparsin
Dimethylarsinic glutathione,Darinaparsin |
||
Darinaparsin is a dimethylated arsenic linked to glutathione. It is cytotoxic to DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5-10 µM) and patient-derived primary prostate cancer cells (IC50s = 2.5-20 µM), as well as Jurkat T cell lymphoma and L540 Hodgkin lymphoma cells (IC50s = 2.7 and 1.3 µM, respectively). [1][2] It decreases the tumor-initiating subpopulation in DU145 and PC3 cells and halts the cell cycle in the G2/M phase. Darinaparsin decreases transcription of Gli-2,... | |||
T79558 |
fac-[Re(CO)3(L3)(H2O)][NO3]
|
||
fac-[Re(CO)3(L3)(H2O)][NO3](简称compound 3),是一种与线粒体功能障碍相关的抗前列腺癌剂。这种铼(I)三羰基水配合物对前列腺癌细胞系(PC-3)表现出显著的细胞毒性,其IC50值为0.32 μM。研究表明,fac-[Re(CO)3(L3)(H2O)][NO3]主要在线粒体中积聚,能够降低PC-3细胞的ATP生成,进而触发细胞副凋亡(paraptosis)机制,而不通过引发坏死、凋亡或自噬途径作用。 |