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Cat. No. Product Name Target Signaling Pathways
T2345 PTC-209

PTC209,PTC 209

BMI-1; Autophagy Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
PTC-209 是特定的BMI-1抑制剂,不可逆转地损害结直肠癌起始细胞,在 HEK293T 细胞系中的IC50为 0.5 μM。它有抗骨髓瘤活性并损害肿瘤微环境。
T6178 PTC-209 hydrobromide

PTC-209 HBr

BMI-1; Autophagy Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
PTC-209 hydrobromide (PTC-209 HBr) 是一种特定的BMI-1抑制剂,能不可逆转地损害结直肠癌起始细胞,也可损害肿瘤微环境,有抗骨髓瘤活性。它在 HEK293T 细胞系中的IC50为 0.5 μM。
T38637 Roy-Bz

Roy-Bz is a potent and selective activator of protein kinase C delta (PKCδ). It effectively inhibits proliferation in colon cancer cells by initiating a mitochondrial apoptotic pathway that relies on PKCδ and involves the activation of caspase-3.
T36485 Becatecarin

Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin. It intercalates into DNA, stabilizing the DNA-topoisomerase complex. This results in the potent catalytic inhibition of both topoisomerases I and II, initiating DNA cleavage and apoptosis. Becatecarin, alone or in combination with other compounds, has anti-cancer as well as myelosuppressive effects in vivo. It is also a transport substrate of the ATP-binding cassette (ABC) transporter ABCG2.
T35940 Darinaparsin

Dimethylarsinic glutathione,Darinaparsin

Darinaparsin is a dimethylated arsenic linked to glutathione. It is cytotoxic to DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5-10 &#181M) and patient-derived primary prostate cancer cells (IC50s = 2.5-20 &#181M), as well as Jurkat T cell lymphoma and L540 Hodgkin lymphoma cells (IC50s = 2.7 and 1.3 &#181M, respectively). [1][2] It decreases the tumor-initiating subpopulation in DU145 and PC3 cells and halts the cell cycle in the G2/M phase. Darinaparsin decreases transcription of Gli-2,...
T79558 fac-[Re(CO)3(L3)(H2O)][NO3]

fac-[Re(CO)3(L3)(H2O)][NO3](简称compound 3),是一种与线粒体功能障碍相关的抗前列腺癌剂。这种铼(I)三羰基水配合物对前列腺癌细胞系(PC-3)表现出显著的细胞毒性,其IC50值为0.32 μM。研究表明,fac-[Re(CO)3(L3)(H2O)][NO3]主要在线粒体中积聚,能够降低PC-3细胞的ATP生成,进而触发细胞副凋亡(paraptosis)机制,而不通过引发坏死、凋亡或自噬途径作用。

化合物

PTC-209
Cat.No: T2345
Synonym: PTC209,PTC 209
Target: BMI-1, Autophagy
PTC-209 hydrobromide
Cat.No: T6178
Synonym: PTC-209 HBr
Target: BMI-1, Autophagy
Roy-Bz
Cat.No: T38637
Synonym:
Target:
Becatecarin
Cat.No: T36485
Synonym:
Target:
Darinaparsin
Cat.No: T35940
Synonym: Dimethylarsinic glutathione,Darinaparsin
Target:
fac-[Re(CO)3(L3)(H2O)][NO3]
Cat.No: T79558
Synonym:
Target:
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