Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6425 |
BTZ043 Racemate
BTZ044,BTZ10526038,Benzothiazinone 10526038 |
Antibacterial; DprE1 | Microbiology/Virology; Others |
BTZ043 Racemate (Benzothiazinone 10526038) 是一种癸二烯基磷酰-β-D-核糖 2'-差向异构酶(DprE1) 抑制剂,用作新的抗分枝杆菌剂。 | |||
T3583 |
Macozinone
PBTZ169 |
Antibacterial; DprE1 | Microbiology/Virology; Others |
Macozinone (PBTZ169) 是具有杀菌作用的苯并噻嗪酮,也有抗结核作用。它也是一种 DprE1有效抑制剂,可通过与活性位点 Cys387 残基形成共价键来抑制必需的黄素蛋白 DprE1。 | |||
T63319 | Antitubercular agent-32 | ||
Antitubercular agent-32 是Benzothiazinone 衍生物,对结核分枝杆菌 M. tuberculosis 具有抑制作用,并表现出良好的代谢稳定性及水溶性。 Antitubercular agent-32 可以作用于 decaprenylphosphoryl-β-D-ribose 2'-氧化酶 (DprE1,IC50: 3.9 μM),表现出抗结核效果。 | |||
T37354 |
CAY10680
CAY10680 |
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CAY10680 is a dopamine-sparing, benzothiazinone compound that selectively inhibits both MAO-B activity (IC50 = 34.9 nM in human) and adenosine A2A receptors (Ki = 39.5 nM in human). It demonstrates significantly less potent inhibitory values for other adenosine receptor subtypes (Kis > 1 μM) and MAO-A (IC50 ≥ 10 μM). At 1-20 μM, CAY10680 has been shown to abolish cAMP accumulation in CHO cells transfected with adenosine A2A receptors. In the central nervous system adenosine A2A receptor expressi... |