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14

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1406	Amantadine hydrochloride 盐酸金刚烷胺,1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride	Dopamine Receptor; Influenza Virus	GPCR/G Protein; Microbiology/Virology; Neuroscience
	Amantadine hydrochloride (CI-719) 是一种抗病毒药物，用于预防或对症治疗甲型流感和帕金森病。它阻断质子流通过 M2 离子通道，从而阻止病毒 RNA 释放到感染细胞的细胞质中。
T50059	6-ethenylquinoline	Others	Others
	6-ethenylquinoline 是一种结构独特的芳香杂环化合物，是生产其他芳香族化合物的重要中间体，并被用作合成各种药物的起始材料，包括抗真菌剂、抗寄生虫剂和抗病毒剂。它已被证明是多种参与药物代谢的酶的抑制剂，包括细胞色素P450、醛氧化酶和黄嘌呤氧化酶等。
TNU0250	3’-Deoxycytidine
	Nucleoside Derivatives - 3’-Deoxy nucleosides; Drugs and Inhibitors; Antiviral agent
TNU0180	7-Deazaguanosine
	Nucleoside Derivatives - 7-Deaza-purine nucleosides; Drugs and Inhibitors; Antiviral agent, anti-HCV
TNU0456	N6-(4-Trifluoromethylbenzyl)adenosine
	Nucleoside Derivatives - 6-Modified purine nucleosides; Drugs and Inhibitors; Antiviral agent, cytokinin nucleoside
TNU0158	2’-C-beta-Methylguanosine
	Nucleoside Derivatives –2’-Modified nucleosides; Drugs and Inhibitors; Antiviral agent, HCV inhibitor
TNU1248	2’,3’-Dideoxy-3’-fluoroadenosine
	Nucleoside Derivatives - Fluoro-modified nucleosides; 2’,3’-Dideoxy nucleosides; Drugs and Inhbitors; Antiviral agent
TNU0230	2’-Azido-2’-deoxycytidine
	Nucleoside Derivatives - Azido-nucleosides, 2’-Modified nucleosides; Drugs and Inhibitors; antiviral agent, DNA synthesis inhibitor; Ribonucleotide reductase inhibitor
TNU0161	N6-MethyladenosineN1-oxide
	Nucleoside Derivatives –6-Modified purine nucleosides;N-Methylated nucleosides; Drugs and Inhibitors; Antiviral agent
TNU1302	3’-Azido-2’,3’-dideoxy-5-hydroxyuridine
	Nucleoside Derivatives - 5-Modified pyrimidine nucleosides; Azido-nucleosides; 2’,3’-Dideoxy nucleosides; Drugs and Inhibitors; Antiviral agent
T71809	L-Xylulose
	L-Xylulose is an intermediate in certain metabolic pathways and is classified as a rare sugar. It shows important physiological effects such as acting as an inhibitor of α-glucosidase and decreasing blood glucose, and it can be employed to produce other significant rare sugars, such as L-ribose and L-xylose which contribute to the production of antiviral drugs.
T63537	SARS-CoV-2 3CLpro-IN-1
	SARS-CoV-2 3CLpro-IN-1 (Compound 14c) is a highly potent inhibitor specifically designed to target and inhibit the activity of SARS-CoV-2 3CL pro, which is a cysteine-protease found in the main coronaviruses. This particular enzyme has been recognized as a highly promising target for the development of effective antiviral drugs. Therefore, SARS-CoV-2 3CLpro-IN-1 holds significant potential for advancing research and development in the field of infectious diseases [1].
T40340	SARS-CoV-2-IN-10
	SARS-CoV-2-IN-10 is a powerful and non-toxic inhibitor of SARS-CoV-2 3CL protease, with IC50 and EC50 values of 0.13 nM and 1.03 nM, respectively. The SARS-CoV-2 3C-like protease (3CLpro) is a critical enzyme for viral replication and serves as an ideal target for intervention. By targeting the SARS-CoV-2 3CL protease, SARS-CoV-2-IN-10 has the potential to facilitate the development of effective antiviral drugs specific to SARS-CoV-2.
TNU1050	3-Deoxy-1,2;5,6-di-O-isopropylidene-D-glucofuranose
	3-Deoxy-1,2;5,6-di-O-isopropylidene-D-glucofuranose 是一种多糖类的低聚糖。它用于糖基化的合成，可以定制合成用作药物中的碳水化合物。它通过抑制病毒蛋白合成而对Epstein-Barr 病毒具有抗病毒活性。

化合物

Amantadine hydrochloride

Cat.No: T1406

Synonym: 盐酸金刚烷胺,1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride

Target: Dopamine Receptor, Influenza Virus

6-ethenylquinoline

Cat.No: T50059

Target: Others

3’-Deoxycytidine

Cat.No: TNU0250

7-Deazaguanosine

Cat.No: TNU0180

N6-(4-Trifluoromethylbenzyl)adenosine

Cat.No: TNU0456

2’-C-beta-Methylguanosine

Cat.No: TNU0158

2’,3’-Dideoxy-3’-fluoroadenosine

Cat.No: TNU1248

2’-Azido-2’-deoxycytidine

Cat.No: TNU0230

N6-MethyladenosineN1-oxide

Cat.No: TNU0161

3’-Azido-2’,3’-dideoxy-5-hydroxyuridine

Cat.No: TNU1302

Cat.No: T71809

SARS-CoV-2 3CLpro-IN-1

Cat.No: T63537

SARS-CoV-2-IN-10

Cat.No: T40340

3-Deoxy-1,2;5,6-di-O-isopropylidene-D-glucofuranose

Cat.No: TNU1050

Cat. No.	Product Name	Target	Signaling Pathways
T7060	Amantadine 1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine	Others	Others
	Amantadine (1-Aminoadamantane) 是抗病毒药物，也是是 NMDA 型谷氨酸受体的弱拮抗剂，能促进高多巴胺的释放，并阻断多巴胺的再摄取。
T36000	3-Hydroxyterphenyllin
	3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methi...

天然产物

Cat.No: T7060

Synonym: 1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine

Target: Others

3-Hydroxyterphenyllin

Cat.No: T36000

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