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16

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T35414	α-Cyclodextrin (hydrate)
	α-Cyclodextrin (α-CD) is a saccharide comprised of six glucose subunits linked by α-1,4 bonds, which results in a cone-shaped molecule.1It contains a hydrophobic interior and hydrophilic exterior, which allow it to form inclusion complexes with wide variety of molecules, conferring enhanced solubility and stabilization to the molecules. α-CD has commonly been used in the separation and purification of chemicals on an industrial scale.1,2Formulations containing α-CD have been used in the pharmace...
T25728	Limaprost alfadex Opalmon,OP 1306 - alpha-cyclodextrin,Prorenal
	Limaprost alfadex is an oral medicine for the circulatory system (for confinement-related thromboangiitis ulcer, anaphrodisia, sharp pain and ischemia characteristics symptom, the improvement of subjective symptom and walking ability with postnatal lumbar
T19159	Mal-β-CD 6-O-alpha-D-Maltosyl-beta-cyclodextrin	Others	Others
	Mal-β-CD is a cellular cholesterol modifier. It can form a soluble inclusion complex with cholesterol.
T4072	Methyl-β-cyclodextrin Methyl-beta-cyclodextrin,甲基-β-环糊精,甲基倍他环糊精,beta-Cyclodextrin methyl ethers	Others	Others
	Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) 是一种大环化合物，可以作为疏水性化合物的增溶剂用于生物实验中。Methyl-β-cyclodextrin 也是一种脂筏抑制剂，具有降胆固醇活性，还具有潜在抗肿瘤活性。
T16858	SBE-β-CD 磺丁基-Β-环糊精,Sulfobutylether-β-Cyclodextrin	Others	Others
	SBE-β-CD (Sulfobutylether-β-Cyclodextrin) 是一种 β-环糊精的衍生物，其磺酸钠盐通过丁基醚间隔基团或磺基丁基醚与亲脂腔隔开。SBE-β-CD 可作为助溶剂，被广泛用于生物学实验中。
T5326	Sugammadex sodium Org25969,Sugammadex (sodium),舒更葡糖钠	Others	Others
	Sugammadex sodium (Org25969) 是合成的 γ 环糊精衍生物，是一种新型的神经肌肉阻断逆转剂。
T27563	Hydroxypropyl-beta-cyclodextrin HP-beta-CyD,VTS-270,HP-beta-CD,Hydroxypropyl-beta-cyclodextri,THPB,HPbCD
	Hydroxypropyl-beta-cyclodextrin, also known as Hydroxypropyl-beta-cyclodextrin; THPB; HP-beta-CD; HPbCD; HP-beta-CyD; VTS-270; HPbetaCD; HPbetaCyD, is a drug candidate potentially for the treatment of Niemann-Pick type C diseases. In April 2009, hydroxypr
T37812	6-O-Sulfo-β-cyclodextrin (sodium salt)
	6-O-Sulfo-β-cyclodextrin is a sulfated cyclodextrin.1It has been used for the chiral separation of nadolol racemates by capillary electrophoresis. 1.Wang, F., Dowling, T., Bicker, G., et al.Electrophoretic chiral separation of pharmaceutical compounds with multiple stereogenic centers in charged cyclodextrin mediaJ. Sep. Sci.24(5)378-384(2001)
T5326L	Sugammadex Org-25969,Org25969,Org 25969,361LPM2T56
	Sugammadex is an agent for reversal of neuromuscular blockade by the agent rocuronium in general anaesthesia. It is the first selective relaxant binding agent (SRBA). Sugammadex is a modified γ-cyclodextrin, with a lipophilic core and a hydrophilic periph
T28047	Mitoquinone-cyclodextrin MitoQ10,Mitoubiquinone mesylate,MitoQ-10,MitoQ,Mito Q10,Mitoquinone mesylate-cyclodextrin
	Mitoquinone-cyclodextrin is a 1:1 molar ratio complex of Mitoquinone mesylate with cyclodextrin. Mitoquinone mesylate is a mitochondria-targeted antioxidant designed to accumulate within mitochondria in vivo in order to protect against oxidative damage. M
T66647	Octakis-(6-bromo-6-deoxy)-γ-cyclodextrin
	Octakis-(6-bromo-6-deoxy)-γ-cyclodextrin 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T66647。
T36350	Cho-Arg (trifluoroacetate salt)
	Cho-Arg is a steroid-based cationic lipid that contains a cholesterol skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay at charge ratios greater than or equal to 4. Cho-Arg facilitates transfection of plasmid DNA into H1299 and HeLa cells in the presence or absence of fetal bovine serum, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the cav...
T69589	PX-316
	PX-316 is a AKT inhibior. PX-316, when administered intraperitoneally to mice at 150 mg/kg, inhibits Akt activation in HT-29 human tumor xenografts up to 78% at 10 h with recovery to 34% at 48 h. PX-316 has antitumor activity against early human MCF-7 breast cancer and HT-29 colon cancer xenografts in mice. PX-316 formulated in 20% hydroxypropyl-beta-cyclodextrin for intravenous administration is well tolerated in mice and rats with no hemolysis and no hematological toxicity. Thus, PX-316 is the...
T36368	2H-Cho-Arg (trifluoroacetate salt)
	2H-Cho-Arg is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection. It forms a complex with plasmid DNA (pDNA) and decreases pDNA migration in an electrophoretic mobility shift assay at +/- charge ratios of 4 or higher. 2H-Cho-Arg facilitates transfection of a luciferase gene into H1299 cells, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and t...
T36359	Dios-Arg (trifluoroacetate salt)
	Dios-Arg is a steroid-based cationic lipid that contains a diosgenin skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay at charge ratio greater than or equal to 4. Dios-Arg facilitates transfection of plasmid DNA into H1299 and HeLa cells in the presence and absence of fetal bovine serum, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the cav...
T71261	Arsthinol
	Arsthinol is an antiprotozoal agent which may have anti-cancer activity. It was found that arsthinol, a trivalent organoarsenic compound (dithiarsolane), has been active in vitro on leukemia cell lines and offers a better therapeutic index than arsenic trioxide, as estimated by the ratio LD50/IC50. Arsthinol induced growth inhibition of NB4 cells at lower concentration (IC50 (concentration inhibiting growth by 50%) = 0.78 +/- 0.08 micromol/l after 24 h) than As(2)O(3) (IC50 = 1.60 +/- 0.23 micro...

化合物

α-Cyclodextrin (hydrate)

Cat.No: T35414

Limaprost alfadex

Cat.No: T25728

Synonym: Opalmon,OP 1306 - alpha-cyclodextrin,Prorenal

Cat.No: T19159

Synonym: 6-O-alpha-D-Maltosyl-beta-cyclodextrin

Target: Others

Methyl-β-cyclodextrin

Cat.No: T4072

Synonym: Methyl-beta-cyclodextrin,甲基-β-环糊精,甲基倍他环糊精,beta-Cyclodextrin methyl ethers

Target: Others

Cat.No: T16858

Synonym: 磺丁基-Β-环糊精,Sulfobutylether-β-Cyclodextrin

Target: Others

Sugammadex sodium

Cat.No: T5326

Synonym: Org25969,Sugammadex (sodium),舒更葡糖钠

Target: Others

Hydroxypropyl-beta-cyclodextrin

Cat.No: T27563

Synonym: HP-beta-CyD,VTS-270,HP-beta-CD,Hydroxypropyl-beta-cyclodextri,THPB,HPbCD

6-O-Sulfo-β-cyclodextrin (sodium salt)

Cat.No: T37812

Cat.No: T5326L

Synonym: Org-25969,Org25969,Org 25969,361LPM2T56

Mitoquinone-cyclodextrin

Cat.No: T28047

Synonym: MitoQ10,Mitoubiquinone mesylate,MitoQ-10,MitoQ,Mito Q10,Mitoquinone mesylate-cyclodextrin

Octakis-(6-bromo-6-deoxy)-γ-cyclodextrin

Cat.No: T66647

Cho-Arg (trifluoroacetate salt)

Cat.No: T36350

Cat.No: T69589

2H-Cho-Arg (trifluoroacetate salt)

Cat.No: T36368

Dios-Arg (trifluoroacetate salt)

Cat.No: T36359

Cat.No: T71261

Cat. No.	Product Name	Target	Signaling Pathways
T17303	α-Cyclodextrin Alfadex,NSC269470,α-环糊精,NSC 269470,NSC-269470	Others	Others
	α-Cyclodextrin (Alfadex) 是一种多功能可溶性膳食纤维，可作为纤维原料销售。
T20682	γ-Cyclodextrin Gamma cyclodextrin,Ringdex C,gamma-Dextrin,Cyclooctaamylose,γ-环糊精	Endogenous Metabolite	Metabolism
	γ-Cyclodextrin (Ringdex C) 是内源性代谢产物的一种。
T2951	β-Cyclodextrin Betadex,Beta-Cyclodextrin,β-环糊精,beta-环糊精,Cyclomaltoheptaose,NSC 269471	Others; Influenza Virus	Microbiology/Virology; Others
	β-Cyclodextrin (NSC 269471) 是一种环状多糖，由 α-D-吡喃型葡萄糖单元通过 α-(1,4) 糖苷键连接而成，通常用于增强药物的溶解度，可抑制流感病毒H1N1。

天然产物

α-Cyclodextrin

Cat.No: T17303

Synonym: Alfadex,NSC269470,α-环糊精,NSC 269470,NSC-269470

Target: Others

γ-Cyclodextrin

Cat.No: T20682

Synonym: Gamma cyclodextrin,Ringdex C,gamma-Dextrin,Cyclooctaamylose,γ-环糊精

Target: Endogenous Metabolite

β-Cyclodextrin

Cat.No: T2951

Synonym: Betadex,Beta-Cyclodextrin,β-环糊精,beta-环糊精,Cyclomaltoheptaose,NSC 269471

Target: Others, Influenza Virus

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