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Search Results for " a-amylase "

21

抑制剂 & 化合物

10

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0517	Pancreatin Pancreatic enzymes,pancrelipase,胰酶	Others	Others
	Pancreatin (pancrelipase) 是一种含有胰腺消化酶的猪胰腺提取物。
T79225	α-Amylase/α-Glucosidase-IN-3	Glucosidase	Metabolism
	α-Amylase/α-Glucosidase-IN-3 (Compound 17) 是一种具有针对α-Amylase和α-Glucosidase的双重抑制活性的化合物，其IC50分别为0.70 μM和1.10 μM。该化合物可应用于II型糖尿病的研究领域。
T60447	α-Amylase-IN-3
	α-Amylase-IN-3 (Compound 4) 是α-Amylase 的非竞争性型抑制剂，IC50值为 18.04 μM。α-Amylase-IN-3具有自由基清除活性，对DPPH 和ABTS 的IC50值分别为 16.04 μM 和 16.99 μM。α-Amylase-IN-3 显示出良好的 α-淀粉酶蛋白质-配体相互作用，可能具有抗氧化、抗炎等药理活性，有助于研究糖尿病和氧化应激相关疾病。
T73745	Ethylidene-4-nitrophenyl-a-D-Maltoheptaoside
	Ethylidene-4-nitrophenyl-a-D-Maltoheptaoside (EPS; pNP-G7) 作为α-淀粉酶的底物，主要应用于测定α-淀粉酶的活性。
T80715	α-Amylase/α-Glucosidase-IN-6
	α-Amylase/α-Glucosidase-IN-6 (compound 5j) 是一种对α-amylase和α-glucosidase具有双重抑制作用的有效化合物，其IC50s分别为17.0 µM和40.1 µM。该化合物还表现出抗高血糖活性。
T78627	Chinese gallotannin	Others	Others
	Chinese gallotannin，一种非特异性α-amylase抑制剂，对人唾液α-淀粉酶具有较强的抑制作用，其Ki值为0.82 μg/mL。此化合物可用于糖尿病研究。
T78359	β-Amylase
	β-Amylase具有高效的淀粉水解功能，广泛应用于生化实验研究领域。
T74255	HPA-IN-1
	HPA-IN-1 (Compound 1)为高效、选择性的人类胰腺α淀粉酶(HPA)抑制剂，其对HPA及α-glucosidase的IC50值分别为12.0 μM与410.4 μM。
T78878	α-Amylase/α-Glucosidase-IN-5	Glucosidase	Metabolism
	α-Amylase/α-Glucosidase-IN-5 (compound 4l) 是一种同时针对α-葡萄糖苷酶 (Glucosidase) 和α-淀粉酶 (Amylases) 的抑制剂，IC50 值分别为 5.96 μM 和 1.62 μM，显示出潜在的抗糖尿病活性。
T79402	α-Amylase/α-Glucosidase-IN-4	Glucosidase	Metabolism
	α-Amylase/α-Glucosidase-IN-4 (compound 5) 是一种针对 α-葡萄糖苷酶 (Glucosidase) 及 α-淀粉酶 (Amylases) 的双效抑制剂，分别展现出 0.15 μM 和 1.10 μM 的IC50s。该化合物展示了其潜在的抗糖尿病活性。
T25522	Ici 216140 m216140,Ici216140,m 216140,Ici-216140,m-216140
	ICI 216140 is a GRP/bombesin receptor 2 antagonist (IC50: 2 nM in vitro). At 2 mg/kg, it can decrease bombesin-stimulated pancreatic amylase secretion in rats. At 1 mM, it has been proved to attenuate bombesin-stimulated increases in blood pressure in rat
T37834	G3-CNP
	G3-CNP is a colorimetric substrate for α-amylases.1Upon hydrolysis by α-amylases, 2-chloro-4-nitrophenol is released which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity. G3-CNP has been used to characterize the activity of human pancreatic or salivary amylase.
TP1241	Adrenocorticotropic Hormone (ACTH) (18-39), human ACTH (18-39), human
	Adrenocorticotropic Hormone (ACTH) (18-39) is known as the Corticotropin-like Intermediate Lobe Peptide. It stimulates insulin secretion as well as amylase and protein secretion in a dose-dependent manner similar to those of secretin and carbamylcholine.
T36864	GRP (human) (trifluoroacetate salt)
	Gastrin-releasing peptide (GRP) is a neuropeptide that stimulates gastrin release. It binds to (Ki = 300 nM) and stimulates amylase secretion in rat pancreatic AR42J cells (EC50 = 0.3 nM). GRP increases proliferation of human liver carcinoma HepG2 and MHCC97H cells but does not affect the proliferation of normal HL-7702 liver cells at a concentration of 1 nM. In vivo, GRP (0.35 nmol/kg/h) increases both pancreatic exocrine secretion and pancreatic polypeptide (PP) release in rats. It dose-depend...
T78376	Rimtoregtide
	Rimtoregtide为一多肽化合物，能显著下调急性胰腺炎致血液淀粉酶与脂肪酶水平升高。该化合物在胰腺炎及急性胰腺炎研究中具备潜力。
T76461	[Nle8] Somatostatin (1-28)
	[Nle8] Somatostatin (1-28)为生长抑素(1-28)的衍生物，其特征在于第8位的甲硫氨酸被正亮氨酸所替代。该化合物能够促使淀粉酶的释放，并增加胰腺腺泡中的环AMP水平。
T75707	BIM-26226
	BIM-26226 是一种胃泌素释放肽，是一种强效选择性的bombesin receptor 拮抗剂。 BIM-26226 抑制 BN 或 GRP 刺激的淀粉酶释放，IC50值在纳摩尔范围内。BIM-26226 可用于癌症研究。
T76262L	Cagrilintide acetate
	Cagrilintide acetate 是一种非选择性的 AMYR/CTR 激动剂和长效酰化淀粉酶类似物。Cagrilintide acetate 以剂量依赖的方式导致食物摄入减少和体重明显下降。Cagrilintide acetate 可用于肥胖症的研究。
T79644	Antidiabetic agent 2	Glucosidase	Metabolism
	Antidiabetic agent 2 (Compound 56) 作为一种葡萄糖摄取促进剂，能有效地抑制DPP-4, PTP-1B, α-淀粉酶和α-葡萄糖苷酶，其IC50s分别达到0.036、0.042、0.241、0.185 μM，表现出显著的降血糖作用。
T37835	2-Chloro-4-nitrophenyl-α-D-glucopyranoside
	Carbohydrates conjugated with 2-chloro-4-nitrophenyl (CNP) serve as chromogenic substrates in assays for enzymes that release CNP from the conjugated carbohydrate. For example, CNP-β-D-maltoheptaoside and CNP-α-maltotrioside are chromogenic substrates for α-amylase. 2-Chloro-4-nitrophenyl-α-D-glucopyranoside is a conjugate of CNP and α-D-glucose. The related conjugate between CNP and β-D-glucose, 2-chloro-4-nitrophenyl β-D-glucopyranoside, is used as a chromogenic substrate for glycosyltransfera...
T35669	Neuromedin C (trifluoroacetate salt)
	Neuromedin C is a bombesin-like neuropeptide that stimulates uterine smooth muscle contraction and the release of gastrin , somatostatin, and amylase in rats. Neuromedin C is a truncated form of gastrin-releasing peptide corresponding to the GRP amino acids 18-27. It inhibits GRP and bombesin binding to rat pancreatic membranes (IC50s = 0.4 and 2.2 nM, respectively), which can be reduced by sodium chloride and guanylyl imidodiphosphate . Neuromedin C induces scratching and mast cell degranulatio...

化合物

Cat.No: T0517

Synonym: Pancreatic enzymes,pancrelipase,胰酶

Target: Others

α-Amylase/α-Glucosidase-IN-3

Cat.No: T79225

Target: Glucosidase

α-Amylase-IN-3

Cat.No: T60447

Ethylidene-4-nitrophenyl-a-D-Maltoheptaoside

Cat.No: T73745

α-Amylase/α-Glucosidase-IN-6

Cat.No: T80715

Chinese gallotannin

Cat.No: T78627

Target: Others

Cat.No: T78359

Cat.No: T74255

α-Amylase/α-Glucosidase-IN-5

Cat.No: T78878

Target: Glucosidase

α-Amylase/α-Glucosidase-IN-4

Cat.No: T79402

Target: Glucosidase

Cat.No: T25522

Synonym: m216140,Ici216140,m 216140,Ici-216140,m-216140

Cat.No: T37834

Adrenocorticotropic Hormone (ACTH) (18-39), human

Cat.No: TP1241

Synonym: ACTH (18-39), human

GRP (human) (trifluoroacetate salt)

Cat.No: T36864

Cat.No: T78376

[Nle8] Somatostatin (1-28)

Cat.No: T76461

Cat.No: T75707

Cagrilintide acetate

Cat.No: T76262L

Antidiabetic agent 2

Cat.No: T79644

Target: Glucosidase

2-Chloro-4-nitrophenyl-α-D-glucopyranoside

Cat.No: T37835

Neuromedin C (trifluoroacetate salt)

Cat.No: T35669

Cat. No.	Product Name	Target	Signaling Pathways
T19615	α-Amylase	Amylase	Metabolism
	α-Amylase 是一种能够催化淀粉中 α-1,4-糖苷键水解的水解酶，使淀粉产生葡萄糖、麦芽糖等产物。
T1136	Amylase Diastase,淀粉酶	Others	Others
	Amylase (Diastase) 是由胰腺和唾液腺分泌得到的一种酶，能够将淀粉水解为糖类。它大致可分为 α 亚型、 β 亚型和 γ 亚型三种亚型。
TN1788	Isookanin	Amylase	Metabolism
	Isookanin 在多种疾病领域有研究价值，包括肿瘤，皮疹，蛇和昆虫叮咬，糖尿病，腹泻。它可作为抗病毒剂对抗 HSV 和水痘带状疱疹病毒。它也具有抗氧化特性。
TN4368	Kaempferol-3,7-di-O-β-glucoside Kaempferol 3,7-di-O-glucoside	Glucosidase; Amylase	Metabolism
	Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside) 是一种来自 Morettia philaena 的黄酮醇，对 α-淀粉酶 (α-amylase)、α-葡萄糖苷酶 (α-glucosidase) 和乙酰胆碱酯酶 (Acetylcholinesterase) 具有抑制作用。Kaempferol-3,7-di-O-β-glucoside 具有神经保护活性，可减缓分化神经元细胞 SH-SY5Y 免受 Amyloid β 肽诱导的损伤。Kaempferol-3,7-di-O-β-glucoside 可用于研究阿尔茨海默氏症类的神经系统疾病。
T2S0731	Trilobatin 三叶苷,三叶甙,P-Phlorizin	Amylase	Metabolism
	Trilobatin (P-Phlorizin) 是源自Lithocarpus polystachyusRehd 的甜味剂，是一种HIV-1抑制剂，靶向 Gp41 包膜蛋白，具有神经保护作用。它还是SGLT1/2抑制剂，可选择性诱导人肝母细胞瘤细胞增殖。
T3S0013	Ethyl trans-caffeate 咖啡酸乙酯,Ethyl caffeate,Caffeic Acid Ethyl Ester	Others	Others
	Ethyl trans-caffeate (Caffeic Acid Ethyl Ester) 具有抗炎作用。它是一种有前途的天然化合物，未来在慢性肝病中的应用。它是一种有效的化学预防化合物，可防止因太阳紫外线照射引起的皮肤癌变。它是与人胰腺α-淀粉酶复合的代表性抑制剂的高分辨率结构。它强烈抑制 JB6 Cl41细胞的肿瘤转化，无毒性。 PI3K、ERK1/2 和 p38 激酶活性在体外通过与 HOEC 直接结合而受到抑制。
T40769	Maltooctaose
	Maltooctaose, a defined maltooligosaccharide with a specific length, can be enzymatically synthesized using Pyrococcus furiosus thermostable amylase (PFTA).
TN4010	Erythrocentaurin	Antifection	Microbiology/Virology
	Erythrocentaurin has antibacterial activity; it also exhibits a concentration-dependent α-amylase inhibition (IC(50) 1.67 ± 0.28 mg/mL).
T75701	8,3′,4′-Trihydroxyflavone-7-O-β-D-glucopyranoside
	8,3′,4′-Trihydroxyflavone-7-O-β-D-glucopyranoside (Compound 3) 是一种可以从Bidens bipinnata 分离得到的天然产物。8,3′,4′-Trihydroxyflavone-7-O-β-D-glucopyranoside 在 0.556 mg/mL 时对α-amylase 有 22% 的抑制作用。
T75492	Ellipyrone A
	Ellipyrone A为一种大环肽，对二肽基肽酶 4 (dipeptidyl peptidase-4: IC50=0.35 mM) 显示出抑制活性，并对α-葡萄糖苷酶 (IC50=0.74 mM) 及α-淀粉酶 (IC50=0.59 mM) 也具有明显的抑制效果，表现出其抗碳水化合物分解的性能。

天然产物

Cat.No: T19615

Target: Amylase

Cat.No: T1136

Synonym: Diastase,淀粉酶

Target: Others

Cat.No: TN1788

Target: Amylase

Kaempferol-3,7-di-O-β-glucoside

Cat.No: TN4368

Synonym: Kaempferol 3,7-di-O-glucoside

Target: Glucosidase, Amylase

Cat.No: T2S0731

Synonym: 三叶苷,三叶甙,P-Phlorizin

Target: Amylase

Ethyl trans-caffeate

Cat.No: T3S0013

Synonym: 咖啡酸乙酯,Ethyl caffeate,Caffeic Acid Ethyl Ester

Target: Others

Cat.No: T40769

Erythrocentaurin

Cat.No: TN4010

Target: Antifection

8,3′,4′-Trihydroxyflavone-7-O-β-D-glucopyranoside

Cat.No: T75701

Cat.No: T75492

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