Cat. No. | Product Name | Target | Signaling Pathways |
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T63533 | ZIKV-IN-4 | ||
ZIKV-IN-4 是低细胞毒性的、酸稳定性的抗ZIKV 剂,其EC50值为3.49 μM。ZIKV-IN-4 对 ZIKV NS5 MTase 表现出有效的抑制作用。 | |||
T60458 |
NS2B/NS3-IN-4
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NS2B/NS3-IN-4 (Compound 34e) 是一种变构的 DENV2和 ZIKVNS2B/NS3蛋白酶抑制剂,对 DENV2 和 ZIKV 的 NS2B/NS3蛋白酶的 IC50值分别为 0.69 µM 和 1.04 µM。 | |||
T21978 |
p-nitro-Pifithrin-α
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p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor. It suppresses p53-mediated TGF-β1 expression in HK-2 cells and inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. Moreover, p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice subjected to a high-fat diet, mitigating the effects of non-alcoholic fatty liver disease [1] [2] [3] [4]. |