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Cat. No. Product Name Target Signaling Pathways
T39909 XZ739

XZ739

PROTACs PROTAC
XZ739 is a Cereblon-dependent PROTAC BCL-XL degrader, targeting a member of the Bcl-2 family, with a DC50 value of 2.5 nM in MOLT-4 cells after 16 hours of treatment. Additionally, XZ739 elicits cell death via caspase-mediated apoptosis.
T39910 Desmorpholinyl Navitoclax-NH-Me

Desmorpholinyl ABT-263-NH-Me,Desmorpholinyl Navitoclax-NH-Me

BCL Apoptosis
Desmorpholinyl Navitoclax-NH-Me (Desmorpholinyl ABT-263-NH-Me) is a Bcl-xL inhibitor, which can be employed alongside a CRBN ligand to synthesize XZ739, a PROTAC BCL-XL degrader [1] [2].
T9382 Thalidomide-NH-C2-PEG3-OH

H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-

E3 Ligase Ligand-Linker Conjugate PROTAC
Thalidomide-NH-C2-PEG3-OH (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是 E3 连接酶配体-linker 偶联物,可用于合成 PROTAC BCL-XL 降解剂 XZ739
T39604 Thalidomide-NH-PEG4-Ms

Thalidomide-NH-PEG4-Ms

Thalidomide-NH-PEG4-Ms is a conjugate that consists of a cereblon ligand based on Thalidomide and a linker molecule, which serves as a ligand-linker moiety for E3 ligase. This conjugate is specifically designed as a degrader for PROTAC BCL-XL, known as XZ739.

化合物

XZ739
Cat.No: T39909
Synonym: XZ739
Target: PROTACs
Desmorpholinyl Navitoclax-NH-Me
Cat.No: T39910
Synonym: Desmorpholinyl ABT-263-NH-Me,Desmorpholinyl Navitoclax-NH-Me
Target: BCL
Thalidomide-NH-C2-PEG3-OH
Cat.No: T9382
Synonym: H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-
Target: E3 Ligase Ligand-Linker Conjugate
Thalidomide-NH-PEG4-Ms
Cat.No: T39604
Synonym: Thalidomide-NH-PEG4-Ms
Target:
TargetMol Loading
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