Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6238 |
WZ4002
|
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
WZ4002 是突变选择性 EGFR 抑制剂,对 EGFR(L858R) 和 EGFR(T790M) 的 IC50 为 2 和 8 nM。 | |||
T35147 |
WZ4002-hydroxy
WZ4002 analog, WZ4002 demethyl derivate,WZ 4002-hydroxy,WZ-4002-hydroxy |
||
WZ4002-hydroxyl is a WZ4002 derivative or WZ4002 analogue in which methoxy is replaced by hydroxyl and can be detected in 50% of patients with clinical resistance to gefitinib or erlotinib. WZ4002 has a basic chemical skeleton (covalent pyrimidine) that d |