Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8561 |
Apcin
|
APC | Cell Cycle/Checkpoint |
Apcin 是后期促进复合物/环体 (APC/C(Cdc20)) E3 连接酶活性的有效竞争性抑制剂,可通过与 Cdc20 结合并阻止底物识别竞争性地抑制 APC/C 依赖性泛素化。它占据 WD40 结构域侧面的 D-box 结合口袋,并可以延长有丝分裂。它通过阻断有丝分裂退出并通过共同添加 Ts-Arg-OMe 协同放大而起作用。 | |||
T74889 | XF067-68 | ||
XF067-68 是一种靶向降解 WD40 重复域蛋白5 (WDR5) 的 PROTAC。 | |||
T74888 | XF056-132 | ||
XF056-132 是一种有效的WDR5(WD40 重复结构域蛋白 5)PROTAC 降解剂。 | |||
T39978 |
Dimethyl-F-OICR-9429-COOH
|
||
Dimethyl-F-OICR-9429-COOH, a ligand for WD40 repeat domain protein 5 (WDR5). This compound is utilized as a key component in the synthesis of PROTACs. | |||
T39976 |
MS67
|
||
MS67 is a potent and selective degrader of the WD40 repeat domain protein 5 (WDR5) with a dissociation constant (Kd) of 63 nM. It exhibits no activity against protein methyltransferases, kinases, G-protein-coupled receptors (GPCRs), ion channels, and transporters. Notably, MS67 demonstrates significant anticancer properties. |