Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T17225 |
Vercirnon
CCX282-B,维塞诺,GSK-1605786,Traficet-EN |
CCR | Immunology/Inflammation; Microbiology/Virology |
Vercirnon (Traficet-EN) 是可口服的选择性 CCR9拮抗剂,可抑制 CCR9 介导的 Molt-4 细胞上 Ca2+移动和趋化性,用于炎症性肠病的研究。 | |||
T41016 |
Vercirnon sodium
GSK-1605786 sodium,CCX282-Bsodium,维塞诺钠盐,Traficet-ENsodium |
||
Vercirnon (GSK1605786A) sodium is an orally bioavailable, selective, and potent antagonist of CCR9 . Vercirnon sodium inhibits CCR9-mediated Ca 2+ mobilization and chemotaxis on Molt-4 cells with IC 50 values of 5.4 and 3.4 nM, respectively. Vercirnon sodium is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC 50 s>10 μM for all). Vercirnon sodium is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC 50 values of 2.8 and 2.6 nM, respectivel... |