Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T17249 |
VZ185
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
VZ185 is an effective and selective dual BRD7/9 PROTAC degrader (DC50s: 4.5 and 1.8 nM, respectively). | |||
T41201 |
cis-VZ 185
|
||
cis-VZ 185 is a negative control for VZ 185. | |||
T17697 |
BRD7-IN-1
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
BRD7-IN-1 是一种修饰的 BI7273 衍生物 (BRD7/9 抑制剂)。BRD7-IN-1 通过与 VHL 配体连接形成 PROTAC VZ185。VZ185 抑制 BRD7/9 的 DC50分别是 4.5 nM 和1.8 nM。 | |||
T17696 |
BRD7-IN-1 free base
|
Others | Others |
BRD7-IN-1 free base, a modified derivative of BI7273 (BRD7/9 inhibitor), interacts with a VHL ligand through a linker, constituting the PROTAC VZ185 (targeting BRD7/9 with DC50 values of 4.5 and 1.8 nM, respectively)[1]. |