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Cat. No.	Product Name	Target	Signaling Pathways
TP1020L	Urocortin (rat) acetate Urocortin (rat) acetate (171543-83-2 Free base)	CRFR	GPCR/G Protein
	Urocortin (rat) acetate 是一种内源性 CRFR 激动剂，对人 CRF1、大鼠 CRF2α 和小鼠 CRF2β 的 Ki 分别为 13 nM、1.5 nM 和 0.97 nM。 Urocortin (rat) acetate 是一种神经肽。
TP1021	Urocortin, human Urocortin (human),Human urocortin,Human urocortin 1,Human urocortin I	CRFR	GPCR/G Protein
	Urocortin, human (Human urocortin I) 是由 40 个氨基酸组成的神经多肽，是选择性 CRF2受体激动剂，作用于 hCRF1(Ki:0.4 nM)、rCRF2α(Ki:0.3 nM)、 mCRF2β(Ki:0.5 nM)。
TP1020	Urocortin, rat Urocortin (Rattus norvegicus),Rat urocortin
	Endogenous CRF agonist. Ki values are 13, 1.5 and 0.97 nM for hCRF1, rCRF2α and mCRF2β respectively.
TP2159	Urocortin, rat TFA (171543-83-2 free base) Urocortin (Rattus norvegicus) (TFA),Rat urocortin TFA,Urocortin, rat TFA	Others	Others
	Urocortin, rat TFA is a neuropeptide and a potent endogenous CRFR agonist (Kis: 0.97 nM, 1.5 nM, and 13 nM for mouse CRF2β, rat CRF2α, and human CRF1).
TP1504	Urocortin III, mouse TFA (357952-10-4 free base) Urocortin III, mouse TFA
	Urocortin III, mouse TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2. Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in th
T36373	Urocortin II (mouse) (trifluoroacetate salt)
	Urocortin II is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin III , frog sauvagine, and piscine urotensin I.1 Mouse urocortin II shares 34 and 42% sequence homology with rat CRF and urocortin . It is expressed in mouse paraventricular, supraoptic, and arcuate nuclei of the hypothalamus, the locus coeruleus, and in motor nuclei of the brainstem and spinal ventral horn. Urocortin II selectively binds to CRF...
TP1649	Urocortin III, mouse
	Mouse UcnIII is expressed predominantly in regions of the brain known to be involved in stress-related behaviours, and its expression in the hypothalamus increases following restraint.
T35814	Urocortin III (human) (trifluoroacetate salt)
	Urocortin III is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin II , frog sauvagine, and piscine urotensin I.1 Human urocortin III shares 90, 40, 37, and 21% identity to mouse urocortin III , mouse urocortin II , human urocortin , and mouse urocortin, respectively. Urocortin III selectively binds to type 2 CRF receptors (Kis = 21.7, 13.5, and >100 nM for rat CRF2α, rat CRF2β, and human CRF1, respectively)....
TP1860	Urocortin II, human
	Human urocortin (hUcn) II is a new member of the corticotropin-releasing-factor (CRF) family. It selectively binds to the CRF2 receptor.
TP1557	Urocortin II, human TFA
	Human urocortin (hUcn) II is a new member of the corticotropin-releasing-factor (CRF) family. It selectively binds to the CRF2 receptor. Human urocortin II exhibits mild motor-suppressive effects and delayed anxiolytic-like effects，suggesting a time-depen
T76127	Urocortin II, mouse
	Urocortin II, mouse 是一种选择性的 2 型促肾上腺皮质激素释放因子 (CRF2) 受体内源性多肽激动剂，对CRFR2和CRFR1的Ki 值分别为 0.66 nM 和 ﹥100 nM。Urocortin II, mouse 通过以 cAMP/PKA 和 Ca2+/CaMKII 依赖性方式激活 CRF2 受体。Urocortin II, mouse 在中枢神经系统的离散区域表达，并激活参与内脏感觉信息处理和调节自主神经外流的中枢神经元。
T75892	Urocortin, rat TFA
	Urocortin, rat TFA (Urocortin (Rattus norvegicus) TFA) 是一种神经肽，也是一种有效的内源性CRFR 激动剂，对人CRF1，大鼠CRF2α和小鼠CRF2β的Ki 分别为 13 nM，1.5 nM 和 0.97 nM。
T76492	(Tyr0)-Urocortin, rat
	(Tyr0)-Urocortin, rat 是针对促肾上腺皮质激素释放因子受体1型(CRF-R1)和2型(CRF-R2)的高亲和力激动剂，其抑制结合常数(Ki)为1-2 nM。
T76180	Urocortin III (human)
	Urocortin III (human) 是一种促肾上腺皮质激素释放因子 (CRF) 相关肽。Urocortin III (human) 优先结合并激活CRF-R2，并且具有离散的中枢神经系统和外周分布。Urocortin III (human) 选择性结合 2 型 CRF 受体，mCRF2β、rCRF2α 和 hCRF1 的Ki 值分别为 13.5、21.7 和 >100 nM。Urocortin III (human) 介导Insulin(human) 分泌的生长抑素依赖性负反馈控制。
T76025	Urocortin III, mouse TFA
	Urocortin III, mouse TFA是CRF（促肾上腺皮质激素释放因子）相关的肽。该化合物主要通过结合并激活CRF-R2发挥作用。Urocortin III（Ucn3）是已知参与调节行为压力反应体系的组分之一。它和CRF-R2在大脑杏仁核中共同作用，从而参与调控复杂的社会动力学行为。
T76319	Urocortin III (mouse) (free acid)
	Urocortin III (mouse) (free acid) 是一种选择性的 CRF2受体激动剂 (对 CRF2受体具有高亲和力)。Urocortin III (mouse) (free acid) 可显著抑制胃排空而不改变结肠运输。
TP2009	K41498 K 41498
	Potent and highly selective CRF2 receptor antagonist (Ki values are 0.66, 0.62 and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells. In rats in vivo, blo
T83674	K 41498 TFA
	K 41498 是一种针对皮质酮释放因子受体2α（CRF2α）和CRF2β的肽拮抗剂，其在表达人类受体的HEK293细胞中的Ki值分别为0.66和0.62 nM。它对CRF2α和CRF2β具有选择性，与CRF1相比（在表达人类受体的HEK293细胞中Ki值为425 nM）。K 41498 (1.84 µg/动物, 静脉注射) 能够阻止大鼠由于尿催肾上腺皮质激素引发的低血压。通过脊髓内给药，K 41498 (0.075-0.5 µmol/动物) 能降低完全弗氏佐剂引起的大鼠模型中机械性爪撤回阈值。

化合物

Urocortin (rat) acetate

Cat.No: TP1020L

Synonym: Urocortin (rat) acetate (171543-83-2 Free base)

Target: CRFR

Urocortin, human

Cat.No: TP1021

Synonym: Urocortin (human),Human urocortin,Human urocortin 1,Human urocortin I

Target: CRFR

Urocortin, rat

Cat.No: TP1020

Synonym: Urocortin (Rattus norvegicus),Rat urocortin

Urocortin, rat TFA (171543-83-2 free base)

Cat.No: TP2159

Synonym: Urocortin (Rattus norvegicus) (TFA),Rat urocortin TFA,Urocortin, rat TFA

Target: Others

Urocortin III, mouse TFA (357952-10-4 free base)

Cat.No: TP1504

Synonym: Urocortin III, mouse TFA

Urocortin II (mouse) (trifluoroacetate salt)

Cat.No: T36373

Urocortin III, mouse

Cat.No: TP1649

Urocortin III (human) (trifluoroacetate salt)

Cat.No: T35814

Urocortin II, human

Cat.No: TP1860

Urocortin II, human TFA

Cat.No: TP1557

Urocortin II, mouse

Cat.No: T76127

Urocortin, rat TFA

Cat.No: T75892

(Tyr0)-Urocortin, rat

Cat.No: T76492

Urocortin III (human)

Cat.No: T76180

Urocortin III, mouse TFA

Cat.No: T76025

Urocortin III (mouse) (free acid)

Cat.No: T76319

Cat.No: TP2009

Synonym: K 41498

Cat.No: T83674

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