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Search Results for " udp-glucuronosyltransferase "

17

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9054	RO6889678	HBV	Microbiology/Virology
	RO6889678 是高效的 HBV 衣壳结构抑制剂，其吸收、分布、代谢和排泄特征较为复杂。它可通过 CYP3A4 介导的氧化作用进行代谢，以及通过 UDP-葡萄糖醛酸基转移酶 UGT1A3 和 UGT1A1 介导的直接葡萄糖醛酸化作用进行代谢。它是一种诱导剂，可作用于人肝细胞中 CYP3A4 和共调节蛋白。
T36826	Acetaminophen Glucuronide (sodium salt)
	Acetaminophen glucuronide is an inactive metabolite of the analgesic and antipyretic agent acetaminophen . It is formed via glucuronidation of acetaminophen by the UDP-glucuronosyltransferase (UGT) isoforms UGT1A6, UGT1A9, UGT1A1, and UGT2B15.
T19685	Faldaprevir BI-201335,BI201335,BI 201335
	Faldaprevir is an effective NS3/NS4A protease inhibitor potentially for the treatment of HCV infection. Faldaprevir is known to inhibit P-glycoprotein, CYP3A4, and UDP-glucuronosyltransferase 1A1.
T71215	Faldaprevir sodium
	Faldaprevir sodium is a potent NS3/NS4A protease inhibitor potentially for the treatment of HCV infection. Faldaprevir is known to inhibit P-glycoprotein, CYP3A4, and UDP-glucuronosyltransferase 1A1.
T37117	Etodolac Acyl Glucuronide
	Etodolac acyl glucuronide is a phase II metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor etodolac .1It is formedviaglucuronidation of etodolac by the UDP-glucuronosyltransferase (UGT) isoforms UGT1A9, UGT1A10, and UGT2B7. 1.Kutsuno, Y., Itoh, T., Tukey, R.H., et al.Glucuronidation of drugs and drug-induced toxicity in humanized UDP-glucuronosyltransferase 1 miceDrug Metab. Dispos.42(7)1146-1152(2014)
T35952	all-trans Retinoyl β-D-Glucuronide
	all-trans Retinoyl β-D-glucuronide is a metabolite of all-trans retinoic acid formed by the UDP-glucuronosyltransferase (UGT) system. It is rapidly converted to all-trans retinoic acid following in vitro or in vivo administration.
T37852	Chlorzoxazone N-Glucuronide
	Chlorzoxazone N-glucuronide is a phase II metabolite of the skeletal muscle relaxant chlorzoxazone . Chlorzoxazone N-glucuronide is formed via glucuronidation of chlorzoxazone by the UDP-glucuronosyltransferase (UGT) isoform UGT1A9.
T36071	Silodosin Glucuronide (sodium salt)
	Silodosin glucuronide is an active metabolite of the α1A-adrenergic receptor antagonist silodosin . It is formed from silodosin by the UDP-glucuronosyltransferase (UGT) isoform UGT2B7. Silodosin glucuronide is toxic to rats with an LD50 value of 0.347 mg/kg.
T37484	1-Salicylate Glucuronide
	1-Salicylate glucuronide is a metabolite of salicylic acid and aspirin .1It is formed from salicylic acid primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT1A9 but also by a variety of other UGT isoforms and from aspirinviasalicylic acid as an intermediate. 1.Kuehl, G.E., Bigler, J., Potter, J.D., et al.Glucuronidation of the aspirin metabolite salicylic acid by expressed UDP-glucuronosyltransferases and human liver microsomesDrug Metab. Dispos.34(2)199-202(2006)
T37005	Estriol 3-β-D-Glucuronide (sodium salt)
	Estriol 3-β-D-glucuronide is a metabolite of estriol . It is formed from estriol by the UDP-glucuronosyltransferase (UGT) isoform UGT1A10. Estriol 3-β-D-glucuronide binds to basolateral and canalicular liver plasma membranes with Kd values of 85 and 164 μM, respectively. It competitively inhibits the hydrolysis of 4-methylumbelliferyl-β-D-glucuronide and is a substrate for hydrolysis by Klotho-human IgG1 Fc protein (KLFc).
T36794	Dolutegravir O-β-D-Glucuronide
	Dolutegravir O-β-D-glucuronide is a metabolite of the HIV integrase inhibitor dolutegravir .1It is formed from dolutegravir primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT1A1in vivobut is also metabolized by UGT1A9 in human liver and kidney microsomes and UGT1A3 in human intestinal microsomes.2,1 1.Liu, S.N., Lu, J.B., Watson, C.J.W., et al.Mechanistic assessment of extrahepatic contributions to glucuronidation of integrase strand transfer inhibitorsDrug Metab. Dispos.47(5)535-544...
T35939	Dabigatran Acyl-β-D-Glucuronide
	Dabigatran acyl-β-D-glucuronide is a major active metabolite of the thrombin inhibitor dabigatran . The prodrug of dabigatran, dabigatran etexilate , is hydrolyzed by plasma esterases to form dabigatran, which is metabolized primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT2B15 to form dabigatran acyl-β-D-glucuronide. Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma equipotently to dabigatran.
T35845	(R,S)-Carvedilol Glucuronide
	(R,S)-Carvedilol glucuronide is a racemic mixture of the carvedilol metabolites (R)-carvedilol glucuronide and (S)-carvedilol glucuronide. (R)-Carvedilol glucuronide is formed via glucuronidation of (R)-carvedilol by the UDP-glucuronosyltransferase (UGT) isoforms UGT1A1 and UGT2B4. (S)-Carvedilol glucuronide is formed via glucuronidation of (S)-carvedilol by UGT2B4 and UGT2B7.
T83873	Dabigatran Acyl-β-D-Glucuronide TFA Dabigatran β-1-O-Acyl Glucuronide
	Dabigatran acyl-β-D-glucuronide是凝血酶抑制剂dabigatran的一种活性代谢产物，主要通过UDP-葡萄糖醛酸转移酶(UGT)的UGT2B15亚型形成。在人体去除血小板的贫血浆中，Dabigatran acyl-β-D-glucuronide (0.46 µM) 能增加活化部分凝血活酶时间(aPTT)。
T37004	Estradiol 3-sulfate 17β-Glucuronide (potassium salt)
	Estradiol 3-sulfate is a sulfated form of the steroid hormone 17β-estradiol , and is common in fetal plasma and in the breast tissues of patients with mammary carcinoma. Sulfated estrogens, including estradiol 3-sulfate, can be converted back to the parent compound by sulfatases. Estradiol 3-sulfate 17β-glucuronide is a metabolite of estradiol 3-sulfate that has been modified by a UDP-glucuronosyltransferase. Glucuronidation of estrogens enhances their utilization by anion transporters, most com...
T37900	UDP-Glucuronic Acid (sodium salt hydrate)
	UDP-Glucuronic acid is a nucleoside diphosphate sugar that is a source of glucuronic acid for polysaccharide biosynthesis. This compound can be used for the formation of many glucuronides with various aglycones.1 1.Green, M.D., and Tephly, T.R.Glucuronidation of amine substrates by purified and expressed UDP-glucuronosyltransferase proteinsDrug Metab. Dispos.26(9)860-867(1998)
T37902	Uridine-5'-diphosphoglucuronic Acid (sodium salt hydrate)
	Uridine-5'-diphosphoglucuronic acid is a nucleoside diphosphate sugar that is a source of glucuronic acid for polysaccharide biosynthesis. This compound can be used for the formation of many glucuronides with various aglycones.1 1.Green, M.D., and Tephly, T.R.Glucuronidation of amine substrates by purified and expressed UDP-glucuronosyltransferase proteinsDrug Metab. Dispos.26(9)860-867(1998)

化合物

Cat.No: T9054

Target: HBV

Acetaminophen Glucuronide (sodium salt)

Cat.No: T36826

Cat.No: T19685

Synonym: BI-201335,BI201335,BI 201335

Faldaprevir sodium

Cat.No: T71215

Etodolac Acyl Glucuronide

Cat.No: T37117

all-trans Retinoyl β-D-Glucuronide

Cat.No: T35952

Chlorzoxazone N-Glucuronide

Cat.No: T37852

Silodosin Glucuronide (sodium salt)

Cat.No: T36071

1-Salicylate Glucuronide

Cat.No: T37484

Estriol 3-β-D-Glucuronide (sodium salt)

Cat.No: T37005

Dolutegravir O-β-D-Glucuronide

Cat.No: T36794

Dabigatran Acyl-β-D-Glucuronide

Cat.No: T35939

(R,S)-Carvedilol Glucuronide

Cat.No: T35845

Dabigatran Acyl-β-D-Glucuronide TFA

Cat.No: T83873

Synonym: Dabigatran β-1-O-Acyl Glucuronide

Estradiol 3-sulfate 17β-Glucuronide (potassium salt)

Cat.No: T37004

UDP-Glucuronic Acid (sodium salt hydrate)

Cat.No: T37900

Uridine-5'-diphosphoglucuronic Acid (sodium salt hydrate)

Cat.No: T37902

Cat. No.	Product Name	Target	Signaling Pathways
TN1160	1,2,3,6-Tetragalloylglucose 1,2,3,6-Tetra-O-galloyl-β-D-glucose,1,2,3,6-四-O-没食子酰-Β-D-葡萄糖,TeGG	LDL; UGT	Metabolism
	1,2,3,6-Tetragalloylglucose (TeGG) 是 UDP-葡萄糖醛酸转移酶 1 家族成员，是多肽A1 的抑制剂(Ki:1.68 μM)。
T4S0145	Corylifol A Corylinin,补骨脂异黄酮A	hCE; STAT; UGT	JAK/STAT signaling; Metabolism; Stem Cells
	Corylifol A (Corylinin) 是补骨脂中的一种天然产物，可抑制IL-6 诱导的STAT3激活和磷酸化，IC50值为0.81 μM。
TN5356	Epiglobulol
	Epiglobulol shows antibacterial activities, it can strongly inhibit the growth of foodborne microorganisms. Epiglobulol can inhibit the recombinant human UDP-glucuronosyltransferase (UGT) 2B7, it may serve as valuable lead structures for the design of pot

天然产物

1,2,3,6-Tetragalloylglucose

Cat.No: TN1160

Synonym: 1,2,3,6-Tetra-O-galloyl-β-D-glucose,1,2,3,6-四-O-没食子酰-Β-D-葡萄糖,TeGG

Target: LDL, UGT

Cat.No: T4S0145

Synonym: Corylinin,补骨脂异黄酮A

Target: hCE, STAT, UGT

Cat.No: TN5356

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