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Cat. No. | Product Name | Target | Signaling Pathways |
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T74662 |
UBA5-IN-1
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UBA5-IN-1 (compound 8.5) 是 UBA5的选择性抑制剂,IC50值为 4.0 μM。UBA5-IN-1 抑制高表达 UBA5 的 Sk-Luci6 癌细胞的增殖。 | |||
T7415 |
DKM 2-93
|
E1/E2/E3 Enzyme | Ubiquitination |
DKM 2-93是相对选择性 UBA5抑制剂,IC50=430 μM。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01324 |
UBA5 Protein, Human, Recombinant (His)
Ubiquitin-like modifier-activating enzyme 5,UBE1DC1... |
Human | E. coli |
UBA5 is a member of the ubiquitin-activating E1 family and UBA5 subfamily. Ubiquitin and ubiquitin-like proteins are recognized as covalently conjugated to various cellular substrates by a three-step enzymatic pathway. The ubiquitin-activating enzyme (E1) has a vital role in the first step of ubiquitination pathway to activate ubiquitin or ubiquitin-like proteins. UBA5 activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy th... |