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9

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T38430	Tubulysin IM-2
	Tubulysin IM-2 is an ADC Cytotoxin and tubulin binder used as anti-microtubule toxins .
T60321	Tubulysin IM-3
	Tubulysin IM-3 是ADC 细胞毒素 (ADC Cytotoxin)，也是一种微管蛋白结合剂。Tubulysin IM-3 可用作抗微管毒素 (anti-microtubule toxins)。
T39125	MC-VC-PAB-Tubulysin M
	MC-vc-PAB-Tubulysin M is a conjugate composed of a cleavable ADC linker (MC-vc-PAB) and the cytotoxic tubulin inhibitor Tubulysin M, which inhibits tubulin polymerization, resulting in cell cycle arrest and apoptosis.
T73947	Tubulysin IM-1
	Tubulysin IM-1 是 ADC 细胞毒素 (ADC Cytotoxin)，也是一种微管蛋白结合剂，用作抗微管毒素 (anti-microtubule toxins)。
T18504	Nitro-PDS-Tubulysin M	Others	Others
	Nitro-PDS-Tubulysin M, an ADC (Antibody-Drug Conjugate) drug-linker conjugate, exhibits potent antitumor activity. It employs Tubulysin M, a tubulin polymerization inhibitor, connected through the Nitro-PDS ADC linker.
T17930	EC1167	Others	Others
	EC1169 is a targeted tubulysin conjugate that utilizes EC1167 as its linker. This compound shows promise in the treatment of recurrent metastatic, castration-resistant prostate cancer (MCRPC)[1].
T17727	CCK2R Ligand-Linker Conjugates 1	Others	Others
	CCK2R Ligand-Linker Conjugate 1 is a hydrophilic peptide linker that conjugates to the cytotoxic antimicrotubule agents Desacetyl Vinblastine Hydrazide (DAVBH) and Tubulysin B Hydrazide (TubBH) as ligand-linker conjugates[1].
T15978	Mal-PEG2-acid	Others	Others
	Mal-PEG2-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG2-acid can be conjugated to Tubulysin and its derivative cytotoxic molecule[1].
T77815	EC1167 hydrochloride
	EC1167 hydrochloride为EC1169的linker，后者是针对前列腺特异性膜抗原的小管溶解蛋白偶联物。EC1169 hydrochloride展现了对治疗复发性转移性去势性前列腺癌（MCRPC）的研究潜力。

化合物

Tubulysin IM-2

Cat.No: T38430

Tubulysin IM-3

Cat.No: T60321

MC-VC-PAB-Tubulysin M

Cat.No: T39125

Tubulysin IM-1

Cat.No: T73947

Nitro-PDS-Tubulysin M

Cat.No: T18504

Target: Others

Cat.No: T17930

Target: Others

CCK2R Ligand-Linker Conjugates 1

Cat.No: T17727

Target: Others

Cat.No: T15978

Target: Others

EC1167 hydrochloride

Cat.No: T77815

Cat. No.	Product Name	Target	Signaling Pathways
TQ0112	Tubulysin A TubA	Microtubule Associated	Cytoskeletal Signaling
	Tubulysin A is a natural product from myxobacterial. It has many function in vitro assays, including anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, and anti-angiogenic.
T13940	Tubulysin F	Others	Others
	Tubulysin F is a natural product isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and is a highly cytotoxic peptide. Tubulysin F is a cytotoxic activity tubulysin that inhibits tubulin polymerization and leads to ce
T13228	Tubulysin D	Microtubule Associated	Cytoskeletal Signaling
	Tubulysin D is a tetrapeptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and displays potent antitumor activity.
T13942	Tubulysin H	Others	Others
	Tubulysin H is a natural product isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and is a highly cytotoxic peptide. Tubulysin H is a cytotoxic activity tubulysin that inhibits tubulin polymerization and leads to ce
T13943	Tubulysin I	Others	Others
	Tubulysin I is a natural product isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and is a highly cytotoxic peptide. Tubulysin I is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to c
T13944	Tubulysin M	Others	Others
	Tubulysin M is a natural product isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and is a highly cytotoxic peptide. Tubulysin M is a cytotoxic activity tubulysin that inhibits tubulin polymerization and leads to ce
T13941	Tubulysin G	Others	Others
	Tubulysin G is a natural product isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and is a highly cytotoxic peptide. Tubulysin G is a cytotoxic activity tubulysin that inhibits tubulin polymerization and leads to ce
T13938	Tubulysin C	Others	Others
	Tubulysin C is a natural product isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and is a highly cytotoxic peptide.
T13939	Tubulysin E	Others	Others
	Tubulysin E is a natural product isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and is a highly cytotoxic peptide.

天然产物

Cat.No: TQ0112

Synonym: TubA

Target: Microtubule Associated

Cat.No: T13940

Target: Others

Cat.No: T13228

Target: Microtubule Associated

Cat.No: T13942

Target: Others

Cat.No: T13943

Target: Others

Cat.No: T13944

Target: Others

Cat.No: T13941

Target: Others

Cat.No: T13938

Target: Others

Cat.No: T13939

Target: Others

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