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Search Results for " tubulin inhibitor 15 "

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Cat. No.	Product Name	Target	Signaling Pathways
T60459	Tubulin inhibitor 15	Others	Others
	Tubulin inhibitor 15 是有效的微管蛋白抑制剂，具有抗增殖活性。Tubulin inhibitor 15 在 HepG2 细胞中表现出细胞毒性。
T61069	Tubulin polymerization-IN-15	Others	Others
	Tubulin polymerization-IN-15 (compound 4) is a highly effective inhibitor of tubulin polymerization, with significant potential in cancer research [1].
T61433	HDAC1-IN-5	Others	Others
	HDAC1-IN-5, a potent inhibitor of HDAC1 with an IC50 value of 15 nM, also exhibits inhibitory activity towards HDAC6 with an IC50 value of 20 nM. In cancer cells, HDAC1-IN-5 enhances the acetylation of both histone H3 and α-tubulin, leading to the activation of caspase 3 and induction of apoptosis. Additionally, HDAC1-IN-5 binds with DNA, causing chromatin damage. Furthermore, it demonstrated strong inhibitory activity against tumor growth in xenograft mice. [1]
T74003	HDAC3/6-IN-2	Others	Others
	HDAC3/6-IN-2 (化合物 15) 是一种高效的HDAC6和HDAC3抑制剂，IC50值分别为0.368 μM和0.635 μM。此化合物不仅具备抗肿瘤活性，能够诱导癌细胞凋亡，同时通过降低HDAC6和HDAC3水平，与H3乙酰化和α-微管蛋白的上调有关。