Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T61872 |
Trk-IN-10
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Trk-IN-10 (Compound 14j) is a highly effective inhibitor of TRK, with an IC50 of 0.86 nM against TrkA and 6.92 nM against TrkA G595R. As an RTK, Trk plays a crucial role as a drug target in solid tumors. Trk-IN-10 (IC50 = 350 nM against ALK) demonstrates superior selectivity in inhibiting Trk, which has potential implications for toxicity reduction [1]. | |||
T19649 |
PF-06273340
PF 6273340,PF 06273340,PF6273340,PF-6273340 |
Trk receptor | Tyrosine Kinase/Adaptors |
PF-06273340 是一种口服具有活力的、具有选择性的外周限制性Trk 泛抑制剂。 | |||
T61443 | Trk-IN-7 | ||
Trk-IN-7 (compound I-6) is a highly potent inhibitor of TRK, exhibiting IC50 values ranging from 0.25-10 nM for TRKA, TRKB, and TRKC, respectively. In addition, Trk-IN-7 demonstrates notable inhibition against EML4-ALK (IC50 <15 nM), as well as ALK G1202R, ALK C1156Y, ALK R1275Q, ALK F1174L, ALK L1197M, and ALK G1269A (IC50 = 5-50 nM) [1]. | |||
T62095 | TRK-IN-19 | ||
TRK-IN-19 (Compound I-10 ) 是一种 TRK 的有效抑制剂,对 TRKA、TRKAG595R 的 IC50 值分别为 1.1 nM、5.3 nM。TRK-IN-19 对癌症疾病表现出潜在的研究价值。 |