Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T72154 |
Topoisomerase IV inhibitor 2
|
Topoisomerase | DNA Damage/DNA Repair |
TopoisomeraseIV inhibitor 2 (compound 5d) 是一种 DNA 拓扑异构酶 IV 抑制剂,其对 TOPO IV 和 DNA 促旋酶的 IC50 值分别为 0.35 μM 和 0.55 μM。此化合物显示出针对 Staphylococcus aureus Newman 菌株和 Escherichia coli ATCC8739 的抗菌活性,对应的 MIC 值分别为 1.985 μM 和 0.744 μM。 | |||
T72153 |
Topoisomerase IV inhibitor 1
|
Topoisomerase | DNA Damage/DNA Repair |
TopoisomeraseIV inhibitor 2 (compound 7d) 作为DNA拓扑异构酶IV(TOPO IV)抑制剂,展现出高效的活性,其对TOPO IV的IC50值为0.23 μM,而对DNA促旋酶的IC50为0.43 μM。此外,该化合物在抗菌领域同样表现出较强的能力,对金黄色葡萄球菌Nerman菌株(Staphylococcus aureus Newman)和大肠杆菌ATCC8739的最小抑菌浓度(MIC)分别为0.972 μM和0.608 μM。 | |||
T61054 | Type II topoisomerase inhibitor 1 | ||
Type II topoisomerase inhibitor 1 可用于抗菌领域。Type II topoisomerase inhibitor 1 是大肠杆菌DNA 旋转酶的选择性抑制剂,IC50值为 1.7 nM,并能与 Asp73 残基形成氢键。Type II topoisomerase inhibitor 1 抑制拓扑异构酶 IV 的活性,IC50值为 0.98 μM。 | |||
T61481 |
TP0480066
|
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TP0480066, a selective topoisomerase II inhibitor, demonstrates excellent inhibitory activity against DNA gyrase (IC50 = 1.10 nM) and topo IV (IC50 = 62.89 nM). This compound exhibits potent efficacy against multiple bacterial species, including drug-resistant strains. Moreover, TP0480066 displays significant inhibitory activity against N. gonorrhoeae, making it suitable for research on gonorrhea [1] [2]. |