Cat. No. | Product Name | Target | Signaling Pathways |
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T61717 |
Topoisomerase I inhibitor 4
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Topoisomerase I inhibitor 4 (compound 7a) is a potent inhibitor of topoisomerase I activity. It effectively inhibits the proliferation of various cancer cell lines including HepG2, A549, MCF-7, and HeLa, with IC50 values of 1.20 μM, 2.09 μM, 1.56 μM, and 1.92 μM, respectively. Thus, Topoisomerase I inhibitor 4 holds promise for cancer research applications [1]. | |||
T63526 |
Topoisomerase I/II inhibitor 4
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Topoisomerase I/II inhibitor 4 是有效的拓扑异构酶 I(Topo I) 和 II(Topo II) 双重抑制剂,对细胞增殖、侵袭和迁移,诱导细胞凋亡 (apoptosis) 具有抑制作用,能够用于研究肝癌。 | |||
T36695 |
TAS-103
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TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research. TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC50 value of 5 nM. TAS-103 (0.1 μM) significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells[1]. TAS-103 (0.01-1 μM) is highly cytotoxic to Lewis lung carcinoma (LLC) cells, and Liposomal TAS-103 is almost as active as free TAS-103[2]. TAS-103 inhibits the viability ... |