Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1523 |
Teniposide
替尼泊苷,NSC 122819,替尼泊甙,VM26 |
Topoisomerase | DNA Damage/DNA Repair |
Teniposide (VM26) 是鬼臼毒素的半合成衍生物,具有抗肿瘤活性,通过与拓扑异构酶 II 和 DNA 形成复合物来抑制 DNA 合成。 | |||
T35607 |
10'-Desmethoxystreptonigrin
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10'-Desmethoxystreptonigrin is an antibiotic originally isolated from Streptomyces and a derivative of the antibiotic streptonigrin. It is active against a variety of bacteria, including S. aureus, S. faecalis, E. coli, K. pneumoniae, and P. vulgaris (MICs = 0.4, 1.6, 3.1, 3.1 and 0.4 μg/ml, respectively). 10'-Desmethoxystreptonigrin is cytotoxic to HCT116 colon and A2780 ovarian cancer cells (IC50s = 0.004 and 0.001 μg/ml, respectively), as well as HCT116 cells resistant to etoposide and tenipo... |