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抑制剂 & 化合物

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天然产物

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Cat. No. Product Name Target Signaling Pathways
T21640 Talinolol

Adrenergic Receptor GPCR/G Protein; Neuroscience
Talinolol 是一种长效、心脏选择性的 β1-肾上腺素能受体阻滞剂,具有心脏保护和抗高血压作用。它也是众所周知且经常使用的 P-糖蛋白 (P-gp) 活性探针底物。

化合物

Talinolol
Cat.No: T21640
Synonym:
Target: Adrenergic Receptor
Cat. No. Product Name Target Signaling Pathways
T37810 6',7'-Epoxybergamottin

6'7'-Epoxybergamottin is a furanocoumarin found in grapefruit. It is a potent inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 with an IC50 value of 0.30 ppm in a cell-free assay, 0.33 μM in HL7 human liver cells, and 0.22 μM in S9 human intestine cells. It has been studied in the context of drug interactions with grapefruit constituents. It is found in grapefruit juice at concentrations of 0.1-7.4 μM and inhibits the transport of talinolol , a permeability glycoprotein (P-gp/ABCB1) transpo...

天然产物

6',7'-Epoxybergamottin
Cat.No: T37810
Synonym:
Target:
TargetMol Loading
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