Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T63876 |
TRβ agonist 1
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TRβ agonist 1 为一种选择性且对突变敏感的甲状腺激素受体 β (TRβ) 激动剂,其EC50值为21 nM。该化合物适用于血脂异常、非酒精性脂肪性肝炎 (NASH) 与甲状腺激素抵抗 (RTH) 研究。 | |||
T5313 |
Sobetirome
IACS-010759,QRX-431 |
Thyroid hormone receptor(THR) | Endocrinology/Hormones |
Sobetirome (IACS-010759) 是一种甲状腺激素受体 β (TRβ) 激动剂,能够选择性的结合到TRβ-1(EC50:0.16 μM)。 | |||
T60925 |
TRβ agonist 3
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TRβ agonist 3 (Compound 3) 是TRβ的有效激动剂,它是一种新的潜在 TRβ 选择性拟甲状腺素。在体外研究中,TRβ agonist 3 可减少 HepG2 中的脂质积累并促进脂肪分解。 | |||
T61464 |
TRβ agonist 2
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TRβ agonist 2 (Compound 1) is a highly potent agonist of TRβ. Moreover, it effectively reduces lipid accumulation in HepG2 cells and promotes lipolysis, offering comparable effects. With its promising attributes, TRβ agonist 2 emerges as a potential thyromimetics that selectively targets TRβ [1]. |