Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T71726 |
TNFalpha-IN-S10
|
||
TNFalpha-IN-S10 is an inhibitor of TNF-α. | |||
T20168 |
Aurothiomalate sodium
金硫丁二钠,Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate |
Others; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; Others |
Aurothiomalate sodium (Miochrysin) 是一种选择性的致癌 PKCι信号传导抑制剂,可抑制肿瘤细胞增殖。它是一种硫氧还蛋白还原酶 (TrxR) 抑制剂,也是一种抗风湿剂。 | |||
T80601 |
Pegsunercept
PEG sTNF-RI |
||
Pegsunercept (PEG sTNF-RI),一种偶联有pegol结构的特异性靶向TNFA单克隆抗体。 | |||
T62959 |
LRH-1 modulator-1
|
||
LRH-1 modulator-1 是一种有效的 LRH-1 (肝受体同源物 -1) 调节剂/激动剂。LRH-1 modulator-1 能够诱导抗炎细胞因子 IL-10,对炎症细胞因子 IL-1b 和 TNFa 表现出抑制作用。LRH-1 modulator-1 在肠道类器官中具有抗炎活性。 | |||
T8996 |
AQX-016A
|
||
AQX-016A 是一种口服有效的 SHIP1激动剂。AQX-016A 是 Pelorol 的结构类似物,在相同摩尔浓度下,其效力是海洋天然产物 Pelorol 的 3 倍。AQX-016A 可以在体外激活重组 SHIP1酶并刺激 SHIP1活性。AQX-016A 还可抑制 PI3K 通路和 TNFa 的产生,可用于各种炎症疾病的研究。 | |||
T71510 |
MF-592
|
||
MF-592 is a potent and selective antagonists of the EP4 receptor. MF-592 demonstrated good functional potency (hEP4 IC50 = 3 nM) and potent inhibition of PGE2 modulated TNFa release in LPS stimulated human whole blood (hWB) (IC50 = 78nM). In addition, it showed an excellent oral pharmacokinetic (PK) profile and in vivo efficacy in a rat chronic adjuvant-induced-arthritis model (ED50 = 0.1 mg/kg/day).. MF-592 has a desirable overall preclinical profile that suggests it is suitable for further de... |