3
3
Cat. No. | Product Name | Target | Signaling Pathways |
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T28269 |
ORY-1001 free base
RG 6016,ORY-1001,ORY 1001,ORY1001,RG-6016,RG6016 |
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ORY-1001 is a KDM1A inhibitor (IC50 <20nM) with high selectivity against related FAD dependent aminoxidases (MAO-A/B, IL4I1, KDM1B >100uM, SMOX 7uM). Treatment of THP-1 (MLL-AF9) cells with ORY-1001, results in a time/dose dependent me2H3K4 accumulation a | |||
T36859 |
C16 Globotriaosylceramide (d18:1/16:0)
C16 Globotriaosylceramide (d18:1/16:0) |
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C16 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from C16 lactosylceramide . C16 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease. C16 globotriaosylceramide is also upregulated in plasma of patien... | |||
T37439 |
C18 Globotriaosylceramide (d18:1/18:0)
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C18 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from lactosylceramide . It inhibits aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate (PMA; 10008014) when used at a concentration of 1 μM. C18 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry disease, a lysosoma... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T4038 |
Ectoine
THP(B),L-Ectoine,四氢甲基嘧啶羧酸 |
Others; Antibacterial | Microbiology/Virology; Others |
Ectoine (L-Ectoine) 是生活在极其恶劣环境中的细菌所产生的氨基酸衍生物,是一种天然的细胞保护剂。它具有良好的安全性,可研究过敏性鼻炎。它用作渗透调节相容性溶质,可增加皮肤表面的水合作用并稳定脂质层,常用于皮肤护理。 | |||
T2P2870 |
Damascenone
trans-damascenone,Beta-Damascenone,大马烯酮,大马酮 |
Others; NF-κB; Endogenous Metabolite | Metabolism; NF-κB; Others |
Damascenone (trans-damascenone) 是一种 E-和 Z-异构体大马士革酮的混合物,源于 Epipremnum pinnatum 的具有抗炎特性的特性化合物。 | |||
T37442 |
Aspergillin PZ
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Aspergillin PZ is a fungal metabolite originally isolated from A. awamori. It induces morphological deformation of P. oryzae conidia when used at a concentration of 89 nM. Aspergillin PZ is active against S. epidermidis (MIC = 20 μM) but not S. aureus, E. coli, or B. cereus (MICs = >20 μM). It is cytotoxic to HL-60 promyelocytic leukemia cells (IC50 = 56.61 μM) but not THP-1 acute monocytic leukemia or PC3 prostate cancer cells (IC50s = >80 μM). |